Advanced Synthesis & Catalysis

Cover image for Vol. 355 Issue 9

June 17, 2013

Volume 355, Issue 9

Pages 1665–1886

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Review
    5. Communications
    6. Full Papers
    7. Updates
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      Cover Picture: (Adv. Synth. Catal. 9/2013) (page 1665)

      Version of Record online: 12 JUN 2013 | DOI: 10.1002/adsc.201390018

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      The front cover picture, provided by Manfred Schrewe, Nadine Ladkau, Bruno Bühler, and Andreas Schmid, illustrates the direct amino-functionalization of unactivated, terminal C[BOND]H bonds by means of one recombinant whole-cell biocatalyst. Orthologous pathway engineering enabled the intracellular coupling of monooxygenase (AlkBGT) and w-transaminase (CV2025) catalysis. The engineered biocatalyst produced 12-aminododecanoic acid methyl ester and octylamine from renewable dodecanoic acid methyl ester and octane respectively. This approach constitutes not only a “one pot” – but also a “one catalyst” – approach for multistep catalysis and demonstrates the enormous potential of whole-cell biocatalysis for the selective introduction of functionalities into inert C[BOND]H bonds. This methodology is illustrated in the communication by Schrewe, Ladkau, Bühler and Schmid on pages 1693–1697 (DOI: 10.1002/adsc.201200958).

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Review
    5. Communications
    6. Full Papers
    7. Updates
    1. You have free access to this content
  3. Review

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Review
    5. Communications
    6. Full Papers
    7. Updates
    1. C[BOND]C Hydrolases for Biocatalysis (pages 1677–1691)

      Elina Siirola, Annika Frank, Gideon Grogan and Wolfgang Kroutil

      Version of Record online: 5 JUN 2013 | DOI: 10.1002/adsc.201300232

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  4. Communications

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Review
    5. Communications
    6. Full Papers
    7. Updates
    1. Direct Terminal Alkylamino-Functionalization via Multistep Biocatalysis in One Recombinant Whole-Cell Catalyst (pages 1693–1697)

      Manfred Schrewe, Nadine Ladkau, Bruno Bühler and Andreas Schmid

      Version of Record online: 22 FEB 2013 | DOI: 10.1002/adsc.201200958

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    2. Synthesis of 6-Kestose using an Efficient β-Fructofuranosidase Engineered by Directed Evolution (pages 1698–1702)

      Miguel de Abreu, Miguel Alvaro-Benito, Julia Sanz-Aparicio, Francisco J. Plou, Maria Fernandez-Lobato and Miguel Alcalde

      Version of Record online: 22 FEB 2013 | DOI: 10.1002/adsc.201200769

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    3. Asymmetric Synthesis of 3-Substituted Cyclohexylamine Derivatives from Prochiral Diketones via Three Biocatalytic Steps (pages 1703–1708)

      Elina Siirola, Francesco G. Mutti, Barbara Grischek, Sebastian F. Hoefler, Walter M. F. Fabian, Gideon Grogan and Wolfgang Kroutil

      Version of Record online: 22 FEB 2013 | DOI: 10.1002/adsc.201201057

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    4. Guidelines for the Application of NAD(P)H Regenerating Glucose Dehydrogenase in Synthetic Processes (pages 1709–1714)

      Vanja Kaswurm, Wouter Van Hecke, Klaus Dieter Kulbe and Roland Ludwig

      Version of Record online: 20 MAR 2013 | DOI: 10.1002/adsc.201200959

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    5. Rhodium-Catalyzed C[BOND]H Olefination of Aryl Weinreb Amides (pages 1724–1728)

      Yan Wang, Chao Li, Yan Li, Feng Yin and Xi-Sheng Wang

      Version of Record online: 5 JUN 2013 | DOI: 10.1002/adsc.201300174

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    6. A Highly Active and General Catalyst for the Stille Coupling Reaction of Unreactive Aryl, Heteroaryl, and Vinyl Chlorides under Mild Conditions (pages 1729–1735)

      Dong-Hwan Lee, Yingjie Qian, Ji-Hoon Park, Jong-Suk Lee, Sang-Eun Shim and Myung-Jong Jin

      Version of Record online: 5 JUN 2013 | DOI: 10.1002/adsc.201300075

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    7. Dendrimers or Nanoparticles as Supports for the Design of Efficient and Recoverable Organocatalysts? (pages 1748–1754)

      Michel Keller, Arnaud Perrier, Roland Linhardt, Laurie Travers, Sebastian Wittmann, Anne-Marie Caminade, Jean-Pierre Majoral, Oliver Reiser and Armelle Ouali

      Version of Record online: 23 MAY 2013 | DOI: 10.1002/adsc.201300120

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    8. Gold Catalysis: β-Ketonaphthalenes via Molecular Gymnastics of 1,6-Diyne-4-en-3-ols (pages 1755–1761)

      Tobias Lauterbach, Sebastian Arndt, Matthias Rudolph, Frank Rominger and A. Stephen K. Hashmi

      Version of Record online: 4 JUN 2013 | DOI: 10.1002/adsc.201300396

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  5. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Review
    5. Communications
    6. Full Papers
    7. Updates
    1. Nitrilase Activity Screening on Structurally Diverse Substrates: Providing Biocatalytic Tools for Organic Synthesis (pages 1763–1779)

      Carine Vergne-Vaxelaire, Franck Bordier, Aurélie Fossey, Marielle Besnard-Gonnet, Adrien Debard, Aline Mariage, Virginie Pellouin, Alain Perret, Jean-Louis Petit, Mark Stam, Marcel Salanoubat, Jean Weissenbach, Véronique De Berardinis and Anne Zaparucha

      Version of Record online: 4 JUN 2013 | DOI: 10.1002/adsc.201201098

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    2. The Evolution of an Amine Dehydrogenase Biocatalyst for the Asymmetric Production of Chiral Amines (pages 1780–1786)

      Michael J. Abrahamson, John W. Wong and Andreas S. Bommarius

      Version of Record online: 20 MAR 2013 | DOI: 10.1002/adsc.201201030

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    3. In Vitro Double Oxidation of n-Heptane with Direct Cofactor Regeneration (pages 1787–1798)

      Christina A. Müller, Beneeta Akkapurathu, Till Winkler, Svenja Staudt, Werner Hummel, Harald Gröger and Ulrich Schwaneberg

      Version of Record online: 16 MAY 2013 | DOI: 10.1002/adsc.201300143

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    4. Regio- and Stereospecific Prenylation of Flavonoids by Sophora flavescens Prenyltransferase (pages 1817–1828)

      Ridao Chen, Xiao Liu, Jianhua Zou, Yunze Yin, Bin Ou, Jianhua Li, Ruishan Wang, Dan Xie, Peicheng Zhang and Jungui Dai

      Version of Record online: 4 JUN 2013 | DOI: 10.1002/adsc.201300196

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    5. Synthesis of a Long Acting HIV Protease Inhibitor via Metal or Enzymatic Reduction of the Appropriate Chloro Ketone and Selective Zinc Enolate Condensation with an Amino Epoxide (pages 1829–1839)

      Ioannis N. Houpis, Renmao Liu, Lin Liu, Yanfei Wang, Nengfa Dong, Xiangan Zhao, Yan Zhang, Tingting Xiao, Youchu Wang, Dominique Depre, Ulrike Nettekoven, Michael Vogel, Rob Wilson and Steve Collier

      Version of Record online: 15 MAY 2013 | DOI: 10.1002/adsc.201300074

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    6. Tetraalkynylated and Tetraalkenylated Benzenes and Pyridines: Synthesis and Photophysical Properties (pages 1849–1858)

      Peter Ehlers, Ani Hakobyan, Antje Neubauer, Stefan Lochbrunner and Peter Langer

      Version of Record online: 4 JUN 2013 | DOI: 10.1002/adsc.201300201

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    7. Tris(acetylacetonato)rhodium(III)-Catalyzed α-Alkylation of Ketones, β-Alkylation of Secondary Alcohols and Alkylation of Amines with Primary Alcohols (pages 1859–1867)

      Ponnam Satyanarayana, Ganapam Manohar Reddy, Hariharasharma Maheswaran and Mannepalli Lakshmi Kantam

      Version of Record online: 23 MAY 2013 | DOI: 10.1002/adsc.201300061

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  6. Updates

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Review
    5. Communications
    6. Full Papers
    7. Updates
    1. Direct Regio-, Diastereo-, and Enantioselective Vinylogous Michael Addition of Prochiral 3-Alkylideneoxindoles to Nitroolefins (pages 1881–1886)

      Gloria Rassu, Vincenzo Zambrano, Luigi Pinna, Claudio Curti, Lucia Battistini, Andrea Sartori, Giorgio Pelosi, Franca Zanardi and Giovanni Casiraghi

      Version of Record online: 4 JUN 2013 | DOI: 10.1002/adsc.201300168

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