Inside Cover: The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange (Adv. Synth. Catal. 17/2014) (page 3474)
Jack A. Brown, Alison R. Cochrane, Stephanie Irvine, William J. Kerr, Bhaskar Mondal, John A. Parkinson, Laura C. Paterson, Marc Reid, Tell Tuttle, Shalini Andersson and Göran N. Nilsson
Article first published online: 18 NOV 2014 | DOI: 10.1002/adsc.201401054
The inside cover picture, by Kerr and co-workers, depicts a series of robust, yet highly active Ir(I) complexes bearing specifically encumbered N-heterocyclic carbene and phosphine ligands. These complexes are extremely effective in hydrogen isotope exchange processes (with D or T), with low catalyst loadings, good levels of selectivity, and broad directing group applicability. The labelling of several complex drug molecules further highlights the catalysts utility. Mechanistic insight into the operation of these catalysts has also been provided by a combination of NMR and theoretical DFT studies. Details of this work can be found in the full paper on pages 3551–3562 (J. A. Brown, A. R. Cochrane, S. Irvine, W. J. Kerr, B. Mondal, J. A. Parkinson, L. C. Paterson, M. Reid, T. Tuttle, S. Andersson, G. N. Nilsson, Adv. Synth. Catal. 2014, 356, 3551–3562; DOI:10.1002/adsc.201400730).