Cheonhyoung Park, Min Woo Ha, Byungsoo Kim, Suckchang Hong, Doyoung Kim, Yohan Park, Mi-hyun Kim, Jae Kyun Lee, Jeeyeon Lee and Hyeung-geun Park
The inside cover picture, provided by Hyeung-geun Park and co-workers, illustrates an enantioselective phase-transfer catalytic α-alkylation of benzylideneamino tert-butyl malonates. This highly efficient protocol was promoted by a quaternary ammonium catalyst, (S,S)-NAS bromide, and the corresponding α,α-dialkylmalonates, bearing a quaternary chiral carbon center, were obtained in high yields and with high stereoselectivities. The products were then selectively hydrolyzed to chiral malonic monoacids under basic, acidic, or catalytic hydrogenation conditions. Details can be found in the full paper on pages 2841–2848 (C. Park, M. W. Ha, B. Kim, S. Hong, D. Kim, Y. Park, M.-h. Kim, J. K. Lee, J. Lee, H.-g. Park, Adv. Synth. Catal. 2015, 357, 2841–2848; DOI: 10.1002/adsc.201500560).