The front cover picture, provided by Davor Šakić and Hendrik Zipse, illustrates the utility of C–H and N–H bond dissociation energy (BDE) data for the rationalization and design of C–H amination reactions. Examples include those from classical Hofmann-Löffler-Freytag reactions as well as more current iodine(I)/iodine(III) catalysis schemes. This type of analysis also provides a surprisingly simple rationalization of experimentally observed solvent effects. Further details can be found in the full paper on page 3983–3991 (D. Šakić, H. Zipse, Adv. Synth. Catal. 2016, 358, 3983–3991; DOI: 10.1002/adsc.201600629).