Advanced Synthesis & Catalysis

Cover image for Vol. 358 Issue 3

February 4, 2016

Volume 358, Issue 3

Pages 333–505

  1. Cover Pictures

    1. Top of page
    2. Cover Pictures
    3. Review
    4. Communications
    5. Full Papers
    6. Updates
    1. You have free access to this content
      Cover Picture: Regio- and Stereoselective Biocatalytic Monoamination of a Triketone Enables Asymmetric Synthesis of Both Enantiomers of the Pyrrolizidine Alkaloid Xenovenine Employing Transaminases (Adv. Synth. Catal. 3/2016) (page 333)

      Stefan E. Payer, Joerg H. Schrittwieser, Barbara Grischek, Robert C. Simon and Wolfgang Kroutil

      Article first published online: 26 JAN 2016 | DOI: 10.1002/adsc.201600053

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      The front cover picture, designed by Verena A. Resch and Stefan Payer, illustrates creating three stereocenters in two steps: the regio- and stereoselective mono-amination of a prochiral triketone followed by chemical reduction gave access to xenovenine, the venom of the ant species Solenopsis tennesseensis. Each enantiomer can be accessed by switching from an (S)- to an (R)-selective biocatalyst in the asymmetric key step of the sequence. Details can be found in the Full Paper on pages 444–451 (S. E. Payer, J. H. Schrittwieser, B. Grischek, R. C. Simon, W. Kroutil, Adv. Synth. Catal.­ 2016, 358, 444–451; DOI: 10.1002/adsc.201500781).

    2. Inside Cover: Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade (Adv. Synth. Catal. 3/2016) (page 334)

      Shiori Nonaka, Kenji Sugimoto, Hirofumi Ueda and Hidetoshi Tokuyama

      Article first published online: 27 JAN 2016 | DOI: 10.1002/adsc.201600054

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      The cover picture, provided by Hidetoshi Tokuyama and co-workers, illustrates the synthesis of substituted quinolizidines via the gold-catalyzed double cyclization cascade. The gold catalyst is efficient for the syntheses of multi-substituted quinolizidine derivatives via the double cyclization of acyclic substrates. The advantage of this reaction is the modular synthesis of acyclic substrates by switching three segments. The gold-catalyzed cascade reaction enables the preparation of various quinolizidine derivatives efficiently. Details can be found in the Communication on pages 380–385 (S. Nonaka, K. Sugimoto, H. Ueda, H. Tokuyama, Adv. Synth. Catal.­ 2016, 358, 380–385; DOI: 10.1002/adsc.201500907).

    3. Inside Back Cover: Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck–Sonogashira Reaction in Water (Adv. Synth. Catal. 3/2016) (page 500)

      Dong-Chao Wang, Hai-Xia Wang, Er-Jun Hao, Xiao-Han Jiang, Ming-Sheng Xie, Gui-Rong Qu and Hai-Ming Guo

      Article first published online: 2 FEB 2016 | DOI: 10.1002/adsc.201600052

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      The cover picture, provided by Hai-Ming Guo, Gui-Rong Qu and co-workers, illustrates a palladium-catalyzed domino Heck[BOND]Sonogashira process in water. Using this strategy, a series of 3-(4-aminobut-2ynyl)oxindole derivatives with an all-carbon quaternary center at the 3-position was easily synthesized. The reactions provided products in excellent yields with a broad substrate tolerance. The target product was readily converted into a pharmaceutically active molecule, which is used as a 5-HT7 receptor antagonist. Details can be found in the Update on pages 494–499 (D.-C. Wang, H.-X. Wang, E.-J. Hao, X.-H. Jiang, M.-S. Xie, G.-R. Qu, H.-M. Guo, Adv. Synth. Catal.­ 2016, 358, 494–499; DOI: 10.1002/adsc.201500887).

  2. Review

    1. Top of page
    2. Cover Pictures
    3. Review
    4. Communications
    5. Full Papers
    6. Updates
  3. Communications

    1. Top of page
    2. Cover Pictures
    3. Review
    4. Communications
    5. Full Papers
    6. Updates
    1. Very Important Publication

    2. Organohalogenite-Catalyzed Spiroketalization: Enantioselective Synthesis of Bisbenzannulated Spiroketal Cores (pages 370–374)

      Jijun Xue, Hongrui Zhang, Tian Tian, Keshu Yin, Dongxue Liu, Xianxing Jiang, Ying Li, Xiaojie Jin and Xiaojun Yao

      Article first published online: 18 JAN 2016 | DOI: 10.1002/adsc.201500390

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    3. Palladium-Catalyzed Selective C[BOND]H Activation: A Simple Method to Synthesize C-3 Site Arylated Quinoline Derivatives (pages 375–379)

      Yongqin He, Zhaoyang Wu, Chaowei Ma, Xiaoqiang Zhou, Xingxing Liu, Xiajun Wang and Guosheng Huang

      Article first published online: 12 JAN 2016 | DOI: 10.1002/adsc.201500763

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    4. Very Important Publication

  4. Full Papers

    1. Top of page
    2. Cover Pictures
    3. Review
    4. Communications
    5. Full Papers
    6. Updates
    1. Very Important Publication

    2. Copper-Nitrene Triggered Annulation of α-Acyl Cinnamides: Access to Isoxazol-3(2H)-ones (pages 410–416)

      Mangfei Yu, Qian Zhang, Gong Li, Jingwen Yuan, Ning Zhang, Rui Zhang, Yongjiu Liang and Dewen Dong

      Article first published online: 22 JAN 2016 | DOI: 10.1002/adsc.201500990

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    3. Catalytic Enantioselective Total Synthesis of Riccardiphenol B (pages 417–425)

      Pierre Cottet, Christian Bleschke, Montse Guiteras Capdevila, Matthieu Tissot and Alexandre Alexakis

      Article first published online: 21 JAN 2016 | DOI: 10.1002/adsc.201500928

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    4. Very Important Publication

  5. Updates

    1. Top of page
    2. Cover Pictures
    3. Review
    4. Communications
    5. Full Papers
    6. Updates
    1. Palladium-Catalyzed Carbonylative Synthesis of 2,3-Disubstituted Chromones (pages 466–479)

      Chaoren Shen, Wanfang Li, Hongfei Yin, Anke Spannenberg, Troels Skrydstrup and Xiao-Feng Wu

      Article first published online: 21 JAN 2016 | DOI: 10.1002/adsc.201500858

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    2. Very Important Publication

    3. Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck–Sonogashira Reaction in Water (pages 494–499)

      Dong-Chao Wang, Hai-Xia Wang, Er-Jun Hao, Xiao-Han Jiang, Ming-Sheng Xie, Gui-Rong Qu and Hai-Ming Guo

      Article first published online: 18 JAN 2016 | DOI: 10.1002/adsc.201500887

      Thumbnail image of graphical abstract

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