Dong-Chao Wang, Hai-Xia Wang, Er-Jun Hao, Xiao-Han Jiang, Ming-Sheng Xie, Gui-Rong Qu and Hai-Ming Guo
The cover picture, provided by Hai-Ming Guo, Gui-Rong Qu and co-workers, illustrates a palladium-catalyzed domino HeckSonogashira process in water. Using this strategy, a series of 3-(4-aminobut-2ynyl)oxindole derivatives with an all-carbon quaternary center at the 3-position was easily synthesized. The reactions provided products in excellent yields with a broad substrate tolerance. The target product was readily converted into a pharmaceutically active molecule, which is used as a 5-HT7 receptor antagonist. Details can be found in the Update on pages 494–499 (D.-C. Wang, H.-X. Wang, E.-J. Hao, X.-H. Jiang, M.-S. Xie, G.-R. Qu, H.-M. Guo, Adv. Synth. Catal. 2016, 358, 494–499; DOI: 10.1002/adsc.201500887).