Experimental determination of solid-liquid-liquid equilibrium phase diagrams



Liquid–liquid phase separation is undesirable in crystallization as it leads to slow crystal growth and uncontrollable crystal morphology. Therefore, it is necessary to identify the conditions under which liquid–liquid phase split occurs, so as to avoid crystallization process taking place at such conditions. In this study, an experimental approach is developed to systematically construct the solid-liquid-liquid equilibrium (SLLE) phase diagram. A four-component system is used to demonstrate the experimental technique and the overall workflow in developing an SLLE phase diagram. © 2007 American Institute of Chemical Engineers AIChE J, 2007