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Computer evaluation of hydrogel-based systems for diabetes closed loop treatment

Authors

  • Irma Y. Sánchez-Chávez,

    1. Dept. of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712
    Current affiliation:
    1. Dept. of Mechatronics and Automation, Technológico de Monterrey, Eugenio Garza Sada 2501, Monterrey, Nuevo León, México 64849
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  • Sergio O. Martínez-Chapa,

    1. Dept. of Electrical Engineering, Tecnológico de Monterrey, Eugenio Garza Sada 2501, Monterrey, Nuevo León, México 64849
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  • Nicholas A. Peppas

    Corresponding author
    1. Dept. of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712
    • Dept. of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712
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Abstract

Hydrogels provide the multifunctionality of smart materials and the applicability to medical regulatory systems. Hydrogel membranes that incorporate glucose oxidase for the closed loop treatment of type 1 diabetes mellitus are characterized and modeled. The Sorensen compartmental model is extended to represent the treatment system of a diabetic patient. The performance of the system closed by a hydrogel-based device is explored and compared to the dynamic behavior of a conventional scheme with an explicit controller element. Anionic and cationic hydrogels are discussed for insulin delivery application. Simulations demonstrate limitations in the range of swelling and contraction of hydrogels in a physiological environment due to the Donnan equilibrium effect. Results show the reduction of peak glucose levels and a basal insulin delivery from a hydrogel membrane system. The evaluation of ionic hydrogel membrane macrosystems prompts the consideration of detected pros and cons using different hydrogels, structures and scales. © 2008 American Institute of Chemical Engineers AIChE J, 2008

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