A workflow consisting of experiments, modeling, and synthesis is presented for managing the impurity content in the product crystals of a crystallization process taking into consideration the entire train of crystallization and downstream processing steps. Experiments on solid–liquid equilibrium, impurity inclusion, washing, and deliquoring are designed in such a way that the experimental data or the model parameters derived from these data can be readily used for process design. Guidelines for experimental design and tradeoffs in process synthesis are discussed. The workflow is illustrated using the purification of Vitamin C (ascorbic acid) as a case study. © 2009 American Institute of Chemical Engineers AIChE J, 2010
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