A strategy for tailored design of efficient and low-pressure drop packed column chromatography

Authors

  • Ping Li,

    Corresponding author
    1. State Key Laboratory of Chemical Engineering, College of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, P.R. China
    • State Key Laboratory of Chemical Engineering, College of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, P.R. China
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  • Jianguo Yu,

    1. State Key Laboratory of Chemical Engineering, College of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, P.R. China
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  • Guohua Xiu,

    1. Linde Technology Center, 3rd Flr., Building D, Guiqiao Rd. 255, Pudong, Shanghai 201206, R.R. China
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  • Alirio E. Rodrigues

    Corresponding author
    1. Laboratory of Separation and Reaction Engineering, Associate Laboratory LSRE/LCM, Dept. of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n 4200-465 Porto, Portugal
    • Laboratory of Separation and Reaction Engineering, Associate Laboratory LSRE/LCM, Dept. of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n 4200-465 Porto, Portugal
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Abstract

Packed chromatographic column, with higher efficiency and lower pressure drop is designed by using inert core adsorbents as stationary phase. The analytical solutions for moments and height equivalent to a theoretical plate (HETP) are given under the conditions of linear adsorption kinetics by taking into account of the axial dispersion, film mass-transfer resistance, intraparticle diffusion resistance, and the sorption rate for chromatographic column packed with inert core adsorbents. By minimizing HETP, a nonlinear algebraic equation was derived to predict the optimized value of the inert core radius. For a given adsorbent with the optimized inert core radius, a strategy was presented to tailor the design of new packed chromatographic column with higher efficiency and lower pressure drop. As an example for supercritical carbon dioxide chromatography, reduced equations in terms of dimensionless inert core radius were derived by “order of magnitude” analysis. The quantitative analysis shows that the major benefit of the inert core adsorbent is a shorter diffusion path compared to conventional fully porous particles. The shorter diffusion path reduces dispersion of solutes and minimizes peak broadening leading to lower pressure drop while maintaining high-separation efficiency. © 2010 American Institute of Chemical Engineers AIChE J, 2010

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