Bioengineering, Food, and Natural Product

Acid-sensitive magnetic nanoparticles as potential drug depots

  1. Shy Chyi Wuang1,2,
  2. Koon Gee Neoh1,
  3. En-Tang Kang1,
  4. Deborah E. Leckband2,
  5. Daniel W. Pack2,*

Article first published online: 20 JUL 2010

DOI: 10.1002/aic.12373

Issue

AIChE Journal

AIChE Journal

Volume 57, Issue 6, pages 1638–1645, June 2011

Additional Information

How to Cite

Wuang, S. C., Neoh, K. G., Kang, E.-T., Leckband, D. E. and Pack, D. W. (2011), Acid-sensitive magnetic nanoparticles as potential drug depots. AIChE J., 57: 1638–1645. doi: 10.1002/aic.12373

Author Information

  1. 1

    Dept. of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore

  2. 2

    Dept. of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801

*Dept. of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801

Publication History

  1. Issue published online: 5 MAY 2011
  2. Article first published online: 20 JUL 2010
  3. Accepted manuscript online: 20 JUL 2010 12:00AM EST
  4. Manuscript Revised: 8 JUL 2010
  5. Manuscript Received: 13 JAN 2010

Funded by

  • Agency for Science, Technology, and Research. Grant Number: Project No: UIUC/00/001
  • National University of Singapore
  • NIH. Grant Number: EB005181
  • NSF. Grant Number: BES0349915
  • U.S. Department of Energy. Grant Numbers: DE-FG02-07ER46453, DE-FG02-07ER46471

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Keywords:

  • magnetic nanoparticles;
  • cancer cells;
  • conjugation;
  • doxorubicin;
  • poly(methacrylic acid);
  • hydrazone linkages;
  • magnetic drug targeting

Abstract

Superparamagnetic magnetic nanoparticles were successfully functionalized with poly(methacrylic acid) via atom transfer radical polymerization, followed by conjugation to doxorubicin (Dox). Because of pH-sensitive hydrazone linkages, the rate and extent of Dox release from the particles was higher at a lower pH and/or a higher temperature than at physiological conditions. Appropriate changes to the pH and temperature can increase the drug release from the particles. Because of the released drug, the particles were found to be cytotoxic to human breast cancer cells in vitro. Such magnetic nanoparticles, with the potential to retain drug under physiological conditions and release the drug in conditions where the pH is lower or temperature is higher, may be useful in magnetic drug targeting by reducing the side effects of the drug caused to healthy tissues. In addition, they may serve as hyperthermia agents where the high temperatures used in hyperthermia can trigger further drug release. © 2010 American Institute of Chemical Engineers AIChE J, 2011

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