Materials, Interfaces, and Electrochemical Phenomena

pH-responsive hydrogel microparticles as intelligent delivery carriers for α-MSH antagonists

  1. Juseung Yang1,
  2. Geundo Cho2,
  3. Tai-Gyu Lee2,
  4. Bumsang Kim1,*

Article first published online: 17 SEP 2010

DOI: 10.1002/aic.12407

Issue

AIChE Journal

AIChE Journal

Volume 57, Issue 7, pages 1919–1925, July 2011

Additional Information

How to Cite

Yang, J., Cho, G., Lee, T.-G. and Kim, B. (2011), pH-responsive hydrogel microparticles as intelligent delivery carriers for α-MSH antagonists. AIChE J., 57: 1919–1925. doi: 10.1002/aic.12407

Author Information

  1. 1

    Dept. of Chemical Engineering, Hongik University, Mapo-gu, 72-1 Sangsu-dong, Seoul 121-791, Korea

  2. 2

    Dept. of Chemical and Biomolecular Engineering, Yonsei University, Seodaemun-gu, 134 Sinchon-dong, Seoul 120-749, Korea

*Dept. of Chemical Engineering, Hongik University, Mapo-gu, 72-1 Sangsu-dong, Seoul 121-791, Korea

Publication History

  1. Issue published online: 9 JUN 2011
  2. Article first published online: 17 SEP 2010
  3. Accepted manuscript online: 23 AUG 2010 10:37AM EST
  4. Manuscript Revised: 26 JUL 2010
  5. Manuscript Received: 4 JAN 2010

Funded by

  • 2010 Hongik University Research Fund
  • Ministry of Knowledge Economy, Republic of Korea. Grant Number: 10029539
  • Small and Medium Business Administration, Republic of Korea. Grant Number: S1065960

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Keywords:

  • hydrogel microparticles;
  • pH-responsive;
  • intelligent delivery system;
  • α-MSH antagonists;
  • skin permeability

Abstract

For a first step in the development of an intelligent delivery system for a nonapeptide as an α-MSH antagonist, pH-responsive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as intelligent delivery carriers was evaluated. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5 and as the MAA amount in the hydrogel increased, the swelling ratio increased at a pH above 5. The loading efficiency of the nonapeptide at pH 7 increased with the amount of Methacrylic acid (MAA) in the hydrogel and at pH 2, where the electrostatic attraction was greatest, a high loading efficiency was not obtained because of the low swelling ratio of the hydrogel. The P(MAA-co-EGMA) microparticles demonstrated a pH-sensitive release behavior for the nonapeptide. In addition, the P(MAA-co-EGMA) microparticles showed a protective ability for the nonapeptide and preserved the stability of the nonapeptide. © 2010 American Institute of Chemical Engineers AIChE J, 2010

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