Separations

β-Cyclodextrin inclusive interaction driven separation of organic compounds

  1. H. B. Ji1,*,
  2. Q. P. Long1,
  3. H. Y. Chen2,
  4. X. T. Zhou3,
  5. X. F. Hu4

Article first published online: 13 DEC 2010

DOI: 10.1002/aic.12466

Issue

AIChE Journal

AIChE Journal

Volume 57, Issue 9, pages 2341–2352, September 2011

Additional Information

How to Cite

Ji, H. B., Long, Q. P., Chen, H. Y., Zhou, X. T. and Hu, X. F. (2011), β-Cyclodextrin inclusive interaction driven separation of organic compounds. AIChE J., 57: 2341–2352. doi: 10.1002/aic.12466

Author Information

  1. 1

    Dept. of Chemical Engineering, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P.R. China

  2. 2

    School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P.R. China

  3. 3

    School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P.R. China

  4. 4

    School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P.R. China

*Dept. of Chemical Engineering, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P.R. China

Publication History

  1. Issue published online: 3 AUG 2011
  2. Article first published online: 13 DEC 2010
  3. Accepted manuscript online: 15 OCT 2010 12:19PM EST
  4. Manuscript Revised: 5 OCT 2010
  5. Manuscript Received: 6 OCT 2009

Funded by

  • National Natural Science Foundation of China. Grant Numbers: 21036009, 20776053
  • Higher-level project for Guangdong provincial universities and the Fundamental Research Funds for the Central Universities

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Keywords:

  • β-cyclodextrin;
  • thermosensitive compound separation;
  • inclusion equilibrium constant;
  • solvent effect;
  • hydrogen bond

Abstract

A novel selective separation method for organic compounds, especially thermosensitive substances, has been proposed using unsubstituted β-cyclodextrin (β-CD) as a host and some alcohols and aldehydes as model guests in aqueous solution. The separation factors were evaluated from the extraction of an equimolar mixture of alcohol and aldehyde compounds. The inclusion equilibrium constants for several alcohols and aldehydes over β-CD have been calculated through their UV-vis spectra. The Gibbs free energy changes of β-CD/substrates complexes (ΔG) have been calculated combined B3LYP/6-31G(d)//ONIOM2(B3LYP/6-31G(d):PM3) with semicontinuum solvation model. The difference of Gibbs free energy changes (ΔΔG) for the inclusion complexes formed via the intermolecular weak interactions e.g., hydrogen bond and electrostatic interaction was the reason why alcohol and aldehyde compounds could be selectively separated. © 2010 American Institute of Chemical Engineers AIChE J, 2011

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