The first two authors contributed equally to this work.
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Fluid Mechanics and Transport Phenomena
Dissolution kinetics or pure mass transfer? A mechanistic study of dissolution
Article first published online: 17 DEC 2010
DOI: 10.1002/aic.12475
Copyright © 2010 American Institute of Chemical Engineers (AIChE)
Additional Information
How to Cite
Kaunisto, E., Marucci, M. and Axelsson, A. (2011), Dissolution kinetics or pure mass transfer? A mechanistic study of dissolution. AIChE J., 57: 2610–2617. doi: 10.1002/aic.12475
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The first two authors contributed equally to this work.
Publication History
- Issue published online: 9 SEP 2011
- Article first published online: 17 DEC 2010
- Accepted manuscript online: 22 OCT 2010 10:25AM EST
- Manuscript Revised: 6 OCT 2010
- Manuscript Received: 16 AUG 2010
Funded by
- Swedish research council
- Abstract
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- Cited By
Keywords:
- dissolution;
- ESPI;
- benzoic acid;
- mass transfer;
- mathematical modeling
Abstract
In many cases, classic in vitro tests are used to investigate dissolution from powders and solids. A problem with these kinds of tests is the frequent use of agitation, leading to a lumped description of the properties at the solid–liquid interface. The hydrodynamic forces arising from agitation might have a nontrivial impact on the dissolution properties, thus calling for a comparison of results with those stemming from stagnant dissolution with the aim to increase the understanding of the dissolution process. Stagnant dissolution of compressed solid benzoic acid was examined using the noninvasive electronic speckle pattern interferometry technique in this study. The diffusion coefficient for benzoic acid in 37°C water was measured using the same technique, and, by combining the results, the surface kinetics at the solid–liquid interface were calculated. A comparison with previous dissolution data from a rotating disk suggests that the presence of convection can increase the observed surface kinetics. © 2010 American Institute of Chemical Engineers AIChE J, 2011