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Transformation of hemipentahydrate to monohydrate of risedronate monosodium by seed crystallization in solution
Article first published online: 28 FEB 2011
DOI: 10.1002/aic.12542
Copyright © 2011 American Institute of Chemical Engineers (AIChE)
Additional Information
How to Cite
Nguyen, T. N. P. and Kim, K.-J. (2011), Transformation of hemipentahydrate to monohydrate of risedronate monosodium by seed crystallization in solution. AIChE J., 57: 3385–3394. doi: 10.1002/aic.12542
Publication History
- Issue published online: 4 NOV 2011
- Article first published online: 28 FEB 2011
- Accepted manuscript online: 29 DEC 2010 03:14PM EST
- Manuscript Revised: 21 DEC 2010
- Manuscript Received: 12 APR 2010
- Abstract
- Article
- References
- Cited By
Keywords:
- risedronate;
- hydrate;
- transformation;
- crystallization;
- ultrasonic velocity
Abstract
The transformation from a hemipentahydrate to a monohydrate of risedronate monosodium was studied by seed crystallization in solution. By using the in-line measurement based on ultrasonic measuring technique and the off-line measurements such as optical microscopic and crystallography, transformation of hydrate forms and crystallization of monohydrate were observed. The effect of concentration of solution and solid fraction of suspension on the ultrasonic velocity was found. The hydrate composition, concentration of solution, and supersaturation during the transformation were estimated with elapsed time. The effect of monohydrate seed, agitation rate and temperature on the induction time, transformation, and crystallization was also investigated. Eventually, transformation from hemipentahydrates to monohydrates and crystallization of monohydrate were analyzed successfully from in-line measuring technique. © 2011 American Institute of Chemical Engineers AIChE J, 2011