Bioengineering, Food, and Natural Products

Synthesis of the artemisinin-imprinting polymers on silica surface and its adsorption behavior in supercritical CO2 fluid

  1. Baojun Yang,
  2. Xuejun Cao*

Article first published online: 28 FEB 2011

DOI: 10.1002/aic.12547

Issue

AIChE Journal

AIChE Journal

Volume 57, Issue 12, pages 3514–3521, December 2011

Additional Information

How to Cite

Yang, B. and Cao, X. (2011), Synthesis of the artemisinin-imprinting polymers on silica surface and its adsorption behavior in supercritical CO2 fluid. AIChE J., 57: 3514–3521. doi: 10.1002/aic.12547

Author Information

  1. State Key Laboratory of Bioreactor Engineering, Dept. of Bioengineering, East China University of Science and Technology, Shanghai, China 200237

*State Key Laboratory of Bioreactor Engineering, Dept. of Bioengineering, East China University of Science and Technology, Shanghai, China 200237

Publication History

  1. Issue published online: 4 NOV 2011
  2. Article first published online: 28 FEB 2011
  3. Accepted manuscript online: 11 JAN 2011 09:40AM EST
  4. Manuscript Revised: 18 DEC 2010
  5. Manuscript Received: 25 AUG 2010

Funded by

  • National Natural Scientific Foundation of China. Grant Number: (20676032)

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Keywords:

  • molecular kwimprinting polymers;
  • artemisinin;
  • calix[4]arene;
  • supercritical CO2 fluid

Abstract

Molecular imprinting polymers (MIPs) for artemisinin were prepared by using 3-aminopropyltriethoxysilane and calix[4]arene bonded on silica particle surface as the functional monomers, tetraethoxysilicane as cross-linker, and artemisinin as template. The MIPs were characterized by Fourier Transform Infrared Spectroscope and SEM. Their adsorption capacities were evaluated by static adsorption experiments. The MIPs showed high adsorption capacity and good selectivity for artemisinin. The maximum adsorption capacity of MIPs for artemisinin was 40.0 mg/g. The imprinting factor and the selective factor of the artemisinin-imprinting polymers was 2.0 and 1.5, respectively. The imprinted film coating onto the silica surface showed a fast kinetics for recognizing and binding templates. Especially, mass transfer reaches the equilibrium within 3.5 h and the adsorption capacity of MIPs for artemisinin reached 120.0 mg/g in supercritical CO2 fluid. © 2011 American Institute of Chemical Engineers AIChE J, 2011

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