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Design of formulated products: Experimental component

Authors

  • Elisa Conte,

    1. Despt. of Chemical and Biochemical Engineering, CAPEC, Technical University of Denmark, Lyngby DK-2800, Denmark
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  • Rafiqul Gani,

    Corresponding author
    1. Despt. of Chemical and Biochemical Engineering, CAPEC, Technical University of Denmark, Lyngby DK-2800, Denmark
    • Dept. of Chemical and Biochemical Engineering, CAPEC, Technical University of Denmark, Lyngby DK-2100, Denmark
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  • Yuen S. Cheng,

    1. Dept. of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
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  • Ka M. Ng

    1. Dept. of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
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Abstract

A systematic methodology for the design and verification of chemical-based products is proposed. By integrating modeling, and experiments, the search space is efficiently scanned to identify the feasible product candidates. The product design (or verification) problem consists of three stages: computer-aided design (Stage 1), which generates a list of feasible candidates, experimental planning (Stage 2), which generates a list of experiments and checks the available experimental set-ups, and experimental testing (Stage 3), which measures the necessary data and verifies the desirable attributes of the final product. The first stage (Stage 1) has been covered in previous publications, along with detailed case studies. The development of Stage 2 and Stage 3 is considered in this article and highlighted through two case studies involving the design and validation of an insect repellent lotion and a sunscreen lotion. © 2011 American Institute of Chemical Engineers AIChE J, 2012

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