Particle Technology and Fluidization

A statistical method for velocity detection in moving powder beds using image analysis

  1. Tofan A. Willemsz1,2,*,
  2. Thanh N. Tran3,
  3. Martijn van der Hoeven4,
  4. Ricardo Hooijmaijers2,
  5. Henderik W. Frijlink1,
  6. Herman Vromans5,6,
  7. Kees van der Voort Maarschalk1,2

Article first published online: 22 APR 2011

DOI: 10.1002/aic.12624

Issue

AIChE Journal

AIChE Journal

Volume 58, Issue 3, pages 690–696, March 2012

Additional Information

How to Cite

Willemsz, T. A., Tran, T. N., van der Hoeven, M., Hooijmaijers, R., Frijlink, H. W., Vromans, H. and van der Voort Maarschalk, K. (2012), A statistical method for velocity detection in moving powder beds using image analysis. AIChE J., 58: 690–696. doi: 10.1002/aic.12624

Author Information

  1. 1

    Dept. of Pharmaceutical Technology and Biopharmacy, University of Groningen, PO Box 72, 9700 AB, Groningen, The Netherlands

  2. 2

    Oral & Polymeric Products Development, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands

  3. 3

    Biostatistics and Research Decision Sciences, Early Development Statistics, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands

  4. 4

    Product Development & Support, Solvay Pharmaceuticals B.V., C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands

  5. 5

    Dept. of Biopharmaceutics, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands

  6. 6

    Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS) Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands

*Dept. of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

Publication History

  1. Issue published online: 6 FEB 2012
  2. Article first published online: 22 APR 2011
  3. Accepted manuscript online: 22 MAR 2011 02:53PM EST
  4. Manuscript Revised: 15 MAR 2011
  5. Manuscript Received: 15 NOV 2010

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Keywords:

  • powder surface velocity;
  • dry powder;
  • excipient;
  • impeller speed;
  • PSV

Abstract

An existing method to measure particle velocity is particle image velocimetry which requires presence of tracer materials. This method of contrast enhancement is not always applicable in an industrial setting. Therefore a method to assess the movement of small, structures has been introduced, called powder surface velocimetry (PSV). The principle of PSV is to follow the movement of small structures on the surface of the powder bed. The displacement of the structure is correlated with velocity. The rate of the blade of a blender was quantified to assess the validity of PSV. Next the powder surface velocity of lactose 100 M was measured by PSV and was found to be in line with expected values and flow regimes. © 2011 American Institute of Chemical Engineers AIChE J, 2012

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