A statistical method for velocity detection in moving powder beds using image analysis

Authors

  • Tofan A. Willemsz,

    Corresponding author
    1. Dept. of Pharmaceutical Technology and Biopharmacy, University of Groningen, PO Box 72, 9700 AB, Groningen, The Netherlands
    2. Oral & Polymeric Products Development, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands
    • Dept. of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands
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  • Thanh N. Tran,

    1. Biostatistics and Research Decision Sciences, Early Development Statistics, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands
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  • Martijn van der Hoeven,

    1. Product Development & Support, Solvay Pharmaceuticals B.V., C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands
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  • Ricardo Hooijmaijers,

    1. Oral & Polymeric Products Development, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands
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  • Henderik W. Frijlink,

    1. Dept. of Pharmaceutical Technology and Biopharmacy, University of Groningen, PO Box 72, 9700 AB, Groningen, The Netherlands
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  • Herman Vromans,

    1. Dept. of Biopharmaceutics, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands
    2. Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS) Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
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  • Kees van der Voort Maarschalk

    1. Dept. of Pharmaceutical Technology and Biopharmacy, University of Groningen, PO Box 72, 9700 AB, Groningen, The Netherlands
    2. Oral & Polymeric Products Development, Merck MSD, PO Box 20, 5340 BH Oss, The Netherlands
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Abstract

An existing method to measure particle velocity is particle image velocimetry which requires presence of tracer materials. This method of contrast enhancement is not always applicable in an industrial setting. Therefore a method to assess the movement of small, structures has been introduced, called powder surface velocimetry (PSV). The principle of PSV is to follow the movement of small structures on the surface of the powder bed. The displacement of the structure is correlated with velocity. The rate of the blade of a blender was quantified to assess the validity of PSV. Next the powder surface velocity of lactose 100 M was measured by PSV and was found to be in line with expected values and flow regimes. © 2011 American Institute of Chemical Engineers AIChE J, 2012

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