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Investigation of chitosan gelation mechanisms by a modeling approach coupled to local experimental measurement

Authors

  • A. Venault,

    1. Dept. of Chemical Engineering, Chung Yuan Christian University, Chung-Li City, Taoyuan County 32023, Taiwan
    2. R&D Center for Membrane Technology, Chung Yuan Christian University, Chung-Li City, Taoyuan County 32023, Taiwan
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  • D. Bouyer,

    Corresponding author
    1. UMR 5635 – CNRS, ENSCM, UM II, Institut Européen des Membranes, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
    • UMR 5635 – CNRS, ENSCM, UM II, Institut Européen des Membranes, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
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  • C. Pochat-Bohatier,

    1. UMR 5635 – CNRS, ENSCM, UM II, Institut Européen des Membranes, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
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  • L. Vachoud,

    1. UMR Qualisud, UFR Sciences Pharmaceutiques et Biologiques, 34093 Montpellier Cedex 5, France
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  • C. Faur

    1. UMR 5635 – CNRS, ENSCM, UM II, Institut Européen des Membranes, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
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Abstract

The formation of chitosan hydrogels using experimental and modeling approaches are described. Chitosan gelation was induced by an ammonia intake from a liquid phase (wet process) or a gaseous phase (vapor process), involving three steps: (i) external mass transfer at the interface, (ii) internal transport within the polymer solution, and (iii) chemical reactions inducing gelation. The experimental study allowed quantifying gelation fronts speeds from local measurement. The main resistance to gelation was investigated for both gelation processes. Experimental results exhibited that internal diffusion through the chitosan matrix was the main resistance in the whole gelation mechanism. The numerical model involved a coupling between mass and heat transfer phenomena and chemical reactions, in transient conditions. Numerical results were first validated and then used as a predictive tool to investigate (i) coupled mechanisms localized in the chitosan matrix and (ii) the influence of operating conditions on gelation rates. © 2011 American Institute of Chemical Engineers AIChE J, 2012

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