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Transport Phenomena and Fluid Mechanics
Spatially resolved characteristics of pharmaceutical sprays
Article first published online: 17 NOV 2011
DOI: 10.1002/aic.12775
Copyright © 2011 American Institute of Chemical Engineers (AIChE)
Additional Information
How to Cite
Muliadi, A. R. and Sojka, P. E. (2012), Spatially resolved characteristics of pharmaceutical sprays. AIChE J., 58: 2920–2935. doi: 10.1002/aic.12775
Publication History
- Issue published online: 8 AUG 2012
- Article first published online: 17 NOV 2011
- Accepted manuscript online: 12 SEP 2011 11:18AM EST
- Manuscript Revised: 2 AUG 2011
- Manuscript Received: 17 FEB 2011
- Abstract
- Article
- References
- Cited By
Keywords:
- spray tablet coating;
- spray pattern;
- phase Doppler analyzer;
- pharmaceutical;
- multiphase flow
Abstract
Spatially resolved drop size, velocity, and volume flux data for five different spray coating guns were described in this study. Such spatially resolved measurements show how sprays respond to changes in operating conditions and gun design in ways that less complete measurements can not provide. Data for instance, allow us to recognize the unique drop size distribution of one of the sprays tested, which ultimately was an important factor in determining the dual roles of the shaping air flows: depending on drop size, viscosity, and the magnitude of the shaping air velocity, the shaping air can either pinch or induce secondary atomization to the sprays. When the former outweighs the latter, a dumbbell-shaped spray develops; a more uniform spray results when the opposite occurs. Volume flux data from the different sprays also suggest that a more robust and consistent tablet coating process can likely be designed by utilizing multiple overlapping round sprays. © 2011 American Institute of Chemical Engineers AIChE J, 2012