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Keywords:

  • dynamic metabolic models;
  • the cybernetic approach;
  • metabolic engineering;
  • elementary modes;
  • cellular regulation

Abstract

The cybernetic approach to metabolic modeling tracing its progress from its early beginnings to its current state with regard to its relationship to other modeling approaches, applications to bioprocess modeling, metabolic engineering, and future prospects are described. The framework is shown to handle large metabolic networks in making dynamic predictions from limited data with looming prospects of extending to genome scale networks. © 2012 American Institute of Chemical Engineers AIChE J, 2012