Reaction Engineering, Kinetics, and Catalysis
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A novel and facile liquid whistle hydrodynamic cavitation reactor to produce submicron multiple emulsions
Article first published online: 10 APR 2012
DOI: 10.1002/aic.13800
Copyright © 2012 American Institute of Chemical Engineers (AIChE)
Additional Information
How to Cite
Tang, S. Y. and Sivakumar, M. (2013), A novel and facile liquid whistle hydrodynamic cavitation reactor to produce submicron multiple emulsions. AIChE J., 59: 155–167. doi: 10.1002/aic.13800
Publication History
- Issue published online: 21 DEC 2012
- Article first published online: 10 APR 2012
- Accepted manuscript online: 16 MAR 2012 11:10AM EST
- Manuscript Revised: 14 MAR 2012
- Manuscript Received: 12 OCT 2011
Literature Cited
- 1Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC: National Academy Press, 2001.
- 2. Biochemical basis for the manifestations of iron deficiency. Annu Rev Nutr. 1986;6:13–40.
- 3, , , . Iron Metabolism in Man. St. Louis: Blackwell Scientific, 1979.
- 4. Disorders of iron metabolism. N Engl J Med. 1999;341:1986–1995.
- 5CDC Recommendations to prevent and control iron deficiency in the United States. Centers for Disease Control and Prevention. MMWR Recomm Rep. 1998;47:1–29.
- 6. Defining iron-deficiency anemia in public health terms: reexamining the nature and magnitude of the public health problem. J Nutr. 2001;131:565S–567S.
- 7, , , , . Comparison of a combination Ferrous Fumarate product and a polysaccharide iron complex as oral treatments of iron deficiency anemia: a Taiwanese study. Int J Hematol. 2004;80:416–420.
- 8. Potentials of liquid membrane system: an overview. Latest Rev. 2007.
- 9, , , . Formula optimization of emulsifiers for preparation of multiple emulsions based on artificial neural networks. J Dispersion Sci Technol. 2008;29:319–326.
- 10, , . Oral multiple W/O/W emulsion formulation of a peptide salmon calcitonin: in vitro and in vivo evaluation. J Clin Pharm Ther. 2000;25:435–443.
- 11, , . Polysaccharide gel with multiple emulsions. Food Hydrocolloids. 2005;19:605–615.
- 12, , . Preparation of monodisperse multiple emulsions at high production rates by multi-stage premix membrane emulsification. J. Membrane Sci. 2004;244:97–106.
- 13, , , . Engineered synthesis of nanostructured materials and catalysts. In: Advances in Chemical Engineering. San Diego: Academic Press, 2001:1–48.
- 14, . Emulsification with ultrasonic waves. J Am Pharm Assoc. 1960;49:482–488.
- 15, . Schall- und Ultraschallerzeugung in Fliissigkeiten fur indus- trielle Zwecke. Z Angew Phys. 1948;1:222–228.
- 16, . Waste water treatment: a novel energy effcient hydrodynamic cavitational technique. Ultrason Sonochem. 2002;9:123–131.
- 17, . Effect of hydrodynamic and sonic cavitation on aqueous polymer solutions. Ind Chem Eng. 1993;35:52–57.
- 18. Method and apparatus for producing ultra-thin emulsion and dispersions. U.S. Patent 5,931,771 A, 1999a.
- 19. Use of hydrodynamic cavitation. Am Lab. 1999;31:6–8.
- 20. Lipid excipients and delivery systems for pharmaceutical development: a regulatory perspective. Adv Drug Delivery Rev. 2008;60:768–777.
- 21, , , , , . Enhanced bioavailability of piroxicam using Gelucire 44/14 and Labrasol: in vitro and in vivo evaluation. Eur J Pharm. Biopharm. 2003;56:453–459.
- 22, , , , , , , . Evaluation of oral formulations of gentamicin containing labrasol in beagle dogs. Int J Pharm. 2003;268:13–21.
- 23, , , . Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. Int J Pharm. 2004;271:11–19.
- 24, , , , . Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Eur J Pharm Sci. 2005;24:477–486.
- 25, . Interfacial rheological and tension properties of protein films. J Colloid Interface Sci. 1997;189:74–82.
- 26, . Influence of protein emulsifier interfacial properties on oil-in-water emulsion stability. Pharm Dev Technol. 1997;3:21–32.
- 27, . In: Becher P, editor. Chapter 3, Encyclopedia of Emulsion Technology. New York: Marcel Dekker, 1983.
- 28, , . Rheology and stability of whey protein stabilized emulsions with high CaCl2 concentrations. Food Res Int. 2000;33:21–25.
- 29, , . Experimental quantification of chemical effects of hydrodynamic cavitation. Chem Eng Sci. 2000;55:1633–1639.
- 30
- 31, , , . High-pressure homogenization as a process for emulsion formation. Chem Eng Technol. 2004;27:361–368.
- 32
- 33, , . Comparison of emulsification efficiency of protein-stabilized oil-in-water emulsions using jet, high pressure and colloid mill homogenization. J Food Eng. 2005;66:211–217.
- 34, . The production of parenteral feeding emulsions by Microfluidizer. Int J Pharm. 1988;44:169–176.
- 35, , , . Preparation and characterization of water/oil and water/oil/water emulsions containing biopolymer-gelled water droplets. J Agr Food Chem. 2007;55:175–184.
- 36, , , , , . Emulsification in turbulent flow: 1. Mean and maximum drop diameters in inertial and viscous regimes. J Colloid Interface Sci. 2007;312:363–380.
- 37, , , . Re-coalescence of emulsion droplets during high-energy emulsification. Food Hydrocolloids. 2008;22:1191–1202.
- 38, , , , , . Effect of process parameters on nanoemulsion droplet size and distribution in SPG membrane emulsification. Int J Pharm. 2011;404:191–197.
- 39, , , , , . Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int J Pharm. 2000;196:177–182.
- 40, , . On the preparation of lecithin-stabilized oil-in-water emulsions by multi-stage premix membrane emulsification. J Food Eng. 2008;89:164–170.
- 41, . W1/O/W2 and O1/W/O2 globules stabilized with Span 80 and Tween 80. Colloid Surf A. 1997;125:181–187.
- 42, . Effect of different treatments for the destabilization of coconut milk emulsion. J Food Eng. 2010;97:341–347.
- 43, , , . Comparison of properties of oil-in-water emulsions stabilized by coconut cream proteins with those stabilized by whey protein isolate. Food Res Int. 2006;39:78–86.
- 44, , , . Properties of palm oil-in-water emulsions stabilized by nonionic emulsifiers. J Colloid Interface Sci. 1996;181:595–604.
- 45, . Electrokinetic behavior of palm oil emulsions in dilute electrolyte solutions. J Colloid Interface Sci. 1999;216:25–33.
- 46, . Dispersion Technology. New York: Bedford Hillls, 2004.
- 47, , , , , . Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of zedoary essential oil: Formulation and bioavailability studies. Int J Pharm. 2010;383:170–177.
- 48. Surface chemistry: theory and industrial applications. New York: Reinhold, 1962.
- 49

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