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Keywords:

  • multistage modeling;
  • simulation;
  • extraction;
  • chiral separation;
  • phenylsuccinic acid enantiomers

The increasing demand for optically pure compounds stimulates the development of new chiral separation processes on an industrial scale. The enantioselective liquid–liquid extraction (ELLE) of phenylsuccinic acid (PSA) enantiomers using hydrophilic hydroxyphenyl-β-CD as extractant (C) was studied experimentally in a countercurrent cascade of 10 centrifugal contactor separators at 293 K. Based on a single-stage equilibrium model and the law of conservation of mass, a multistage equilibrium model of ELLE was developed to investigate the influence of changes in the process parameterssuch as phase ratios and concentrations on extraction efficiency. The multistage equilibrium model was verified experimentally with a good agreement. The model was applied to predict the symmetrical separation of PSA enantiomers. By modeling, optimal process parameters for the symmetrical separation of PSA enantiomers can beachieved. The minimum number of stages was determined at 22 and 24 for eeeq>98% and eeeq>99%, respectively. © 2013 American Institute of Chemical Engineers AIChE J, 59: 2594–2602, 2013