• interpenetrating polymer network;
  • amphiphilic;
  • chemotherapeutic;
  • oral deliver;
  • pH-responsive

New interpenetrating polymer networks (IPNs) composed of hydrophilic, pH-responsive poly(methacrylic-grafted-ethylene glycol), and hydrophobic poly(n-butyl acrylate) were formed for the oral delivery of chemotherapeutics. These amphiphilic IPNs were synthesized to express variations in swelling and hydrophobic properties to try and develop an optimized material for the loading and release of doxorubicin, a hydrophobic chemotherapeutic. Release profiles modeling the gastrointestinal (GI) transit from the stomach to the small intestine were investigated. Mucoadhesion was determined using fresh porcine small intestine, polymer samples, and a tensile tester. The biocompatibility of the materials was assessed against Caco-2 and HT29-MTX cell models representing the GI tract and SW620 cells serving as a colon cancer cell model. © 2013 American Institute of Chemical Engineers AIChE J, 59: 1472–1478, 2013