Precipitation of hydroxyapatite at 37 °C in a meso oscillatory flow reactor operated in batch at constant power density

Authors

  • Filipa Castro,

    Corresponding author
    1. Institute for Biotechnology and Bioengineering (IBB), Centre for Biological Engineering, Dept. of Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
    Search for more papers by this author
  • António Ferreira,

    1. Institute for Biotechnology and Bioengineering (IBB), Centre for Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
    2. LEPAE-Laboratory for Process, Environmental and Energy Engineering, Dept. of Chemical Engineering, Faculty of Engineering of the University of Porto, Porto, Portugal
    Search for more papers by this author
  • Fernando Rocha,

    1. LEPAE-Laboratory for Process, Environmental and Energy Engineering, Faculty of Engineering of the University of Porto, Porto, Portugal
    Search for more papers by this author
  • António Vicente,

    1. Institute for Biotechnology and Bioengineering (IBB), Centre for Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
    Search for more papers by this author
  • José António Teixeira

    1. Institute for Biotechnology and Bioengineering (IBB), Centre for Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
    Search for more papers by this author

Abstract

A meso oscillatory flow reactor (meso-OFR) was successfully applied for the precipitation of hydroxyapatite (HAp) nanoparticles. Mixing efficiency of the mesoreactor operated batchwise in a vertical tube was evaluated at constant power density, by monitoring variation of hue values upon mixing both spatially and temporally. The best operating conditions for fast mixing and a more homogeneous reaction medium were verified for f = 0.83 Hz and x0 = 4.5 mm. HAp precipitation was then carried out under these conditions at 37 °C for different mixing Ca/P molar ratios. HAp nanoparticles with a mean size (d50) of about 67 nm and a narrow size distribution were obtained. Furthermore, the obtained results show the advantages of the meso-OFR over a stirred tank batch reactor due to the production, about four times faster, of smaller and more uniform HAp nanoparticles. © 2013 American Institute of Chemical Engineers AIChE J, 59: 4483–4493, 2013

Ancillary