Fluorescent hydroxyapatite-loaded biodegradable polymer nanoparticles with folate decoration for targeted imaging

Authors

  • Jie Pan,

    1. State Key Laboratory of Hollow Fiber Membrane Materials and Processes, Department of Pharmaceutical Engineering, School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin, China
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  • Dong Wan,

    1. State Key Laboratory of Hollow Fiber Membrane Materials and Processes, Department of Pharmaceutical Engineering, School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin, China
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  • Yuxia Bian,

    1. State Key Laboratory of Hollow Fiber Membrane Materials and Processes, Department of Pharmaceutical Engineering, School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin, China
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  • Hongfan Sun,

    1. Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China
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  • Chao Zhang,

    1. Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China
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  • Fengmin Jin,

    1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
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  • Zhiqi Huang,

    1. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China
    2. Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
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  • Jinlong Gong

    Corresponding author
    1. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China
    2. Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
    • Correspondence concerning this article should be addressed to J. Gong at jlgong@tju.edu.cn

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Abstract

The preparation of the luminescent hydroxyapatite (HAP)-loaded biocompatible nanoparticles (NPs) for targeted imaging of cancer cells is described. Currently, cellular imaging using fluorescent probes is an important technique for the early diagnosis of cancer. Compared with the quantum dots, luminescent HAP is a new fluorescent material with many advantages such as low toxicity, biocompatibility, thermal stability, resistance to erosion, and low prices. Thus, luminescent HAP has enormous potential to be used as biological fluorescent probes. However, luminescent HAP is water-insoluble, low sensitivity, which limit its application in the field of cellular imaging. Surface modification of NPs with targeting molecule was carried out to achieve its target function. Thus, novel fluorescent NPs with low toxicity, high sensitivity, and good photostability were prepared to be used for targeted imaging of cancer cells. This study initially explored the applications of luminescent HAP in the field of targeted cellular imaging. This NPs platform will be a promising tool for molecular imaging and medical diagnostics, especially the detection of cancer at its early stage. © 2013 American Institute of Chemical Engineers AIChE J, 59: 4494–4501, 2013

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