The classification of control objectives and external disturbances in a chemical plant determines the extent of the optimizing and regulatory control structures (see Part I). In this article we discuss the structural design of alternative regulatory control schemes to satisfy the posed objective. Within the framework of hierarchical control, criteria are developed for the further decomposition of the process subsystems, reducing the combinatorial problem while not eliminating feasible control structures. We use structural models to describe the interactions among the units of a plant and the physicochemical phenomena occurring in the various units. The relevance of controllability and observability in the synthesis of control structures is discussed, and modified versions are used to develop all the alternative feasible regulatory structures in an algorithmic fashion. Various examples illustrate the developed concepts and strategies, including the application of the overall synthesis method to an integrated chemical plant.