Resolution in chromatographic separations can be compromised by nonuniform flow distribution, heterogeneous packing, or flow instabilities such as viscous fingering. In this work, the displacement of solutes within a chromatographic column was monitored with an advanced magnetic-resonance technique, echo-planar spectroscopic imaging (EPSI). Unlike conventional magnetic-resonance imaging, this approach allows multiple solutes to be observed simultaneously, providing separate “chemical images” for each component. Qualitative chemical images were obtained in approximately 1 min with approximately 1 mm3 spatial resolution. EPSI allowed us to examine the multi-component viscous fingering problem for the first time. While many features of the instability are preserved, solute retention appears to slow the growth of solvent fingers.