Simulated moving-bed (SMB) technology is attracting increased interest for application to the separation of pharmaceuticals and fine chemicals, particularly to enantioseparations. Unlike the large-scale UOP Sorbex process, these small-scale units use a series of HPLC columns, and the volume of the connecting lines may become comparable to the volume of the columns. In this work the effect of extra-column dead volume on SMB performance is analyzed, with the aim of providing a conceptual framework to account for it. In particular, guidelines to design SMB operating conditions with nonnegligible extra-column dead volumes to achieve the desired separation performance are provided. These are quantitatively assessed through comparison with the results obtained using a detailed SMB model, which accounts for extra-column dead volumes. The model allows the extent and the role of extra-column band broadening due to the presence of dead volumes to be evaluated. A set of experimental results on a laboratory SMB unit is discussed in light of the theoretical findings.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.