A systematic procedure is presented for synthesizing and developing a manufacturing process for pharmaceutical tablets and capsules. The product quality factors—functional, physical and sensorial—are first identified. The dosage form and excipients are then selected, and the process flowsheet is synthesized along with the suitable equipment and operating conditions. Finally, the product and process are evaluated to ensure that the product possesses the desired quality factors. Design heuristics and physical models are provided to assist decision-making. Examples involving Vitamin C, antacid, and ginseng are provided to illustrate the procedure.