Effects of cold on the skeletal growth of albino rats
Article first published online: 3 FEB 2005
Copyright © 1969 Wiley-Liss, Inc.
American Journal of Anatomy
Volume 124, Issue 2, pages 239–249, February 1969
How to Cite
Lee, M. M. C., Chu, P. C. and Chan, H. C. (1969), Effects of cold on the skeletal growth of albino rats. Am. J. Anat., 124: 239–249. doi: 10.1002/aja.1001240207
- Issue published online: 3 FEB 2005
- Article first published online: 3 FEB 2005
Two groups of male albino rats of 26 days old, were kept at 5°C and 28°C respectively. Their growth was studied by weekly gross measurements and biweekly radiographic investigations for 16 weeks. Compared with the controls at 28°C, the rats kept at 5°C showed the following effects of cold in their growth: (1) Smaller measurements at all ages; (2) Slower growth rates in the first two to four weeks; (3) Relatively shorter tail and shorter feet but body weight was the same as the controls of the same body lengths irrespective of age; (4) Shorter but relatively thicker bones; (5) A disto-proximal stunting gradient was observed in the tail and limb bones, showing more severe effect in the distal segments and decreasing effect in the proximal segments; (6) Retardation of skeletal maturational status in the naked appendages (tail and foot); (7) Decreased number (1.4) of ossified caudal vertebrae.
The above phenomena were discussed as results of possible reduction of blood flow to the skeletal tissue on cold exposure.