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Abstract

Cytoplasmic projections of adrenocortical cells have been observed within sinusoidal lumina of various species. The projections contain organelles and inclusions which are morphologically identical to those in subjacent functional cortical cells, and appear to be capable of hormone biosynthesis. The frequency with which the projections are observed is markedly enhanced by the administration of prostaglandin E1. Continuity has been observed between the projections and the parenchymal cells. Whether or not these morphological entities reflect a mechanism for an enhanced response to corticotropin stimulation remains uncertain. Their association with cellular autolysis or degradation appears doubtful.