MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse
Article first published online: 3 FEB 2005
Copyright © 1992 Wiley-Liss, Inc.
Volume 193, Issue 1, pages 34–39, January 1992
How to Cite
Füchtbauer, E.-M. and Westphal, H. (1992), MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse. Dev. Dyn., 193: 34–39. doi: 10.1002/aja.1001930106
- Issue published online: 3 FEB 2005
- Article first published online: 3 FEB 2005
- Manuscript Accepted: 12 AUG 1991
- Manuscript Received: 19 JUN 1991
- Muscle regeneration;
- Muscle graft;
- Gene expression
The differential expression of genes triggering myogenesis might cause or reflect differences among myoblasts. Little is known about the presence of MyoD1 and myogenin during the process of regeneration. We therefore examined the expression of MyoD1 and myogenin in muscle regeneration after grafting. Immunostaining of regenerating skeletal muscle of the mouse revealed the presence of both MyoD1 and myogenin. In mononucleated cells the proteins were not detected until shortly before fusion into myotubes. They persisted in the nuclei of regenerated muscle fibers for at least 2 weeks. MyoD1 and myogenin were not detected in nonregenerating control muscle.