Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development

Authors

  • Béatrice Quantin,

    1. INSERM U.211, Institut de Biologie-CHR, 44035 Nantes Cedex 01
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  • Brigitte Schuhbaur,

    1. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, 67404 Illkirch Cedex, C.U. de Strasbourg France
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  • Marie-Claude Gesnel,

    1. INSERM U.211, Institut de Biologie-CHR, 44035 Nantes Cedex 01
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  • Pascal Dollé,

    1. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, 67404 Illkirch Cedex, C.U. de Strasbourg France
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    • Pascal Dollé and Richard Breathnach contributed equally to this work.

  • Richard Breathnach

    Corresponding author
    1. INSERM U.211, Institut de Biologie-CHR, 44035 Nantes Cedex 01
    • INSERM U.211, Institut de Biologie-CHR, 9 quai Moncousu, 44035 Nantes Cedex 01, France
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    • Pascal Dollé and Richard Breathnach contributed equally to this work.


Abstract

The human ron gene codes for a transmembrane protein tyrosine kinase which is a receptor for the macrophage stimulating protein. The ron receptor, together with the hepatocyte growth factor/scatter factor receptor encoded by the proto-oncogene met, and the product of the c-sea proto-oncogene, make up a family of structurally related receptors. We have cloned murine ron cDNA sequences and used them as probes for in situ hybridization and Northern blot experiments. We show that ron gene expression occurs relatively late in development, and is much more restricted than that of the met gene. ron gene expression is detected in specific areas of the central and the peripheric nervous system, as well as in discrete cells in developing bones, and in the glandular epithelia along the digestive tract. © 1995 wiley-Liss, Inc.

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