Expression of the TEL/EVI1 fusion transcript in a patient with chronic myelogenous leukemia with t(3;12)(q26;p13)
Article first published online: 18 DEC 2001
Copyright © 2002 Wiley-Liss,Inc.
American Journal of Hematology
Volume 69, Issue 1, pages 80–82, January 2002
How to Cite
Nakamura, Y., Nakazato, H., Sato, Y., Furusawa, S. and Mitani, K. (2002), Expression of the TEL/EVI1 fusion transcript in a patient with chronic myelogenous leukemia with t(3;12)(q26;p13). Am. J. Hematol., 69: 80–82. doi: 10.1002/ajh.10028
- Issue published online: 20 DEC 2001
- Article first published online: 18 DEC 2001
- Manuscript Accepted: 15 AUG 2001
- Manuscript Received: 2 JUN 2001
- Ministry of Health and Welfare
- Ministry of Education, Science and Culture of Japan
- Philadelphia chromosome;
- chronic myelogenous leukemia
The t(3;12)(q26;p13) translocation is a recurrent chromosomal aberration observed in myeloid malignancies. It has been shown that the translocation results in the fusion of the TEL (ETV6) gene at 12p13 and the EV11 gene at 3q26. We report the first case with Philadelphia (Ph)-positive chronic myelogenous leukemia (CML) expressing the TEL/EVI1 fusion transcript. A 26-year-old man was initially diagnosed as having the chronic phase of Ph-positive CML. The t(3;12)(q26;p13) emerged 16 months prior to the myeloid blastic crisis. Reverse transcriptase-polymerase chain reaction detected the TEL/EVI1 transcript without the intervening 5′ non-coding exon of EVI1, suggesting that inappropriate expression of the EVI1 protein driven by the TEL promotor could play a critical role in progression to the blast crisis of CML. Am. J. Hematol. 69:80-82, 2002. © 2002 Wiley-Liss, Inc.