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Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma

  1. Takuya Matsunaga1,*,
  2. Kazuyuki Murase1,
  3. Makoto Yoshida1,
  4. Akihito Fujimi1,
  5. Satoshi Iyama1,
  6. Kageaki Kuribayashi1,
  7. Tsutomu Sato1,
  8. Katsuhisa Kogawa2,
  9. Yasuo Hirayama3,
  10. Sumio Sakamaki3,
  11. Kyuhei Kohda4,
  12. Yoshiro Niitsu1

Article first published online: 25 JUL 2005

DOI: 10.1002/ajh.20349

Issue

American Journal of Hematology

American Journal of Hematology

Volume 79, Issue 4, pages 294–298, August 2005

Additional Information

How to Cite

Matsunaga, T., Murase, K., Yoshida, M., Fujimi, A., Iyama, S., Kuribayashi, K., Sato, T., Kogawa, K., Hirayama, Y., Sakamaki, S., Kohda, K. and Niitsu, Y. (2005), Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma. American Journal of Hematology, 79: 294–298. doi: 10.1002/ajh.20349

Author Information

  1. 1

    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan

  2. 2

    Department of Internal Medicine, Tokeidai Hospital, Japan

  3. 3

    Department of Internal Medicine, Higashi Sapporo Hospital, Japan

  4. 4

    Department of Internal Medicine, Asahikawa Red Cross Hospital, Japan

*4th Department of Internal Medicine, Sapporo Medical University, South-1 West-17, Chuo-ku, Sapporo, Japan

Publication History

  1. Issue published online: 25 JUL 2005
  2. Article first published online: 25 JUL 2005
  3. Manuscript Accepted: 30 NOV 2004
  4. Manuscript Received: 6 SEP 2004

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Keywords:

  • donor cell derived leukemia;
  • cord blood transplantation;
  • adult T-cell lymphoma

Abstract

We report a patient with adult T-cell lymphoma who developed acute myeloid leukemia (AML) after allogeneic cord blood transplantation (CBT). Fluorescence in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the AML to be of donor origin. Although 25 cases of donor cell leukemia (DCL) occurring after allogeneic bone marrow transplantation have previously been reported, there have been no reports of DCL after CBT. This case is the first-reported DCL patient after CBT. Am. J. Hematol. 79:294–298, 2005. © 2005 Wiley-Liss, Inc.

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