Acquired von Willebrand syndrome: An update

Authors

  • Massimo Franchini,

    Corresponding author
    1. Servizio di Immunoematologia e Trasfusione–Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    • Servizio di Immunoematologia e Trasfusione–Centro Emofilia, Ospedale Policlinico, Piazzale L. Scuro, 10, 37134 Verona, Italy
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  • Giuseppe Lippi

    1. Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona, Verona, Italy
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Abstract

Acquired von Willebrand syndrome (aVWS) is a rare bleeding disorder with laboratory findings similar to those for congenital von Willebrand disease (VWD). However, unlike congenital VWD, it arises in individuals with no personal or family history of bleeding. aVWS occurs in association with a variety of underlying disorders, most frequently in lymphoproliferative disorders, myeloproliferative disorders, and cardiovascular diseases. Through an analysis of the more recent literature data, the pathophysiology and the clinical, laboratory, and therapeutic aspects of this syndrome are concisely reported in this review. Am. J. Hematol., 2007. © 2006 Wiley-Liss, Inc.

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