A second case of prothrombin puerto rico I in the united states

Authors

  • Stephen J. Kling,

    1. Division of Hematology, University of Utah Health Sciences Center, Salt Lake City, Utah
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  • Kimberly A. Jones,

    1. Division of Hematology, University of Utah Health Sciences Center, Salt Lake City, Utah
    2. Division of Oncology, University of Utah Health Sciences Center, Salt Lake City, Utah
    3. Huntsman Cancer Institute, Salt Lake City, Utah
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  • George M. Rodgers

    Corresponding author
    1. Division of Hematology, University of Utah Health Sciences Center, Salt Lake City, Utah
    2. Division of Oncology, University of Utah Health Sciences Center, Salt Lake City, Utah
    3. Huntsman Cancer Institute, Salt Lake City, Utah
    4. Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah
    • Division of Hematology, University of Utah Health Sciences Center, Salt Lake City, Utah
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Abstract

Prothrombin deficiency is a very rare autosomal recessive bleeding disorder associated with mild to severe bleeding symptoms. We identified this bleeding disorder in a US-born patient as due to prothrombin Puerto Rico I. Unlike other prothrombin deficiencies, prothrombin Puerto Rico I is a series of concordant polymorphisms found in people of Puerto Rican descent with a much higher frequency than those prothrombin deficiencies found in the general population. This case underscores the importance of family history in identifying rare bleeding disorders. Am. J. Hematol 2007. © 2006 Wiley-Liss, Inc.

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