Aggressive T-cell large granular lymphocyte leukemia: A case report and review of the literature
Article first published online: 4 JAN 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Hematology
Volume 82, Issue 6, pages 481–485, June 2007
How to Cite
Alekshun, T. J., Tao, J. and Sokol, L. (2007), Aggressive T-cell large granular lymphocyte leukemia: A case report and review of the literature. Am. J. Hematol., 82: 481–485. doi: 10.1002/ajh.20853
- Issue published online: 9 MAY 2007
- Article first published online: 4 JAN 2007
- Manuscript Accepted: 12 OCT 2006
- Manuscript Revised: 25 SEP 2006
- Manuscript Received: 18 APR 2006
- aggressive T-cell LGL leukemia;
The majority of patients with T-cell large granular lymphocyte (LGL) leukemia will have an indolent clinical course. Herein, we report a case of an aggressive T-cell LGL leukemia in a previously healthy 42-year-old Caucasian male who presented with acute onset of B-symptoms, hepatosplenomegaly, lymphocytosis, moderate anemia, and thrombocytopenia. Immunophenotypically, the malignant cells co-expressed CD3+CD8+CD56+ markers and the T-cell receptor beta (TCR β) gene demonstrated clonal rearrangement. The patient was treated with an intensive chemotherapeutic regimen (hyper-CVAD) and he achieved a complete remission. A systematic review of all available English literature revealed 12 well-described cases of aggressive T-cell LGL leukemia suggesting that this variant is a new and distinct entity in the spectrum of LGL disorders. Am. J. Hematol., 2007. © 2007 Wiley-Liss, Inc.