Clinical Pearls in Blood Diseases
Severe Henoch-Schönlein purpura in a thalassemic patient under deferiprone treatment
Article first published online: 21 AUG 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Hematology
Volume 83, Issue 2, pages 165–166, February 2008
How to Cite
Unal, S., Güçer, S., Kale, G., Besbas, N., Özen, S. and Gümrük, F. (2008), Severe Henoch-Schönlein purpura in a thalassemic patient under deferiprone treatment. Am. J. Hematol., 83: 165–166. doi: 10.1002/ajh.21052
- Issue published online: 2 JAN 2008
- Article first published online: 21 AUG 2007
- Manuscript Accepted: 11 JUL 2007
- Manuscript Revised: 10 JUL 2007
- Manuscript Received: 28 MAY 2007
Herein we present a 7-year-old β-thalassemia major patient who developed severe Henoch-Schönlein purpura (HSP) with renal, pulmonary involvement and invagination while under iron chelation with deferiprone. DNA analysis for familial Mediterranean fever revealed M696V mutation. Various cellular and humoral immunological impairments have been described in thalassemia major patients and the severe course of HSP in our case may be related to these underlying immunological defects. Am. J. Hematol., 2008. © 2007 Wiley-Liss, Inc.