• 1
    Serhan CN,Clish CB,Brannon J, et al. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med 2000; 192: 11971204.
  • 2
    Serhan CN,Hong S,Gronert K, et al. Resolvins: A family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 2002; 196: 10251037.
  • 3
    Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot Essent Fatty Acids 2005; 73: 141162.
  • 4
    Bannenberg G,Moussignac RL,Gronert K, et al. Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration. Br J Pharmacol 2004; 143: 4352.
  • 5
    Bannenberg GL,Chiang N,Ariel A, et al. Molecular circuits of resolution: Formation and actions of resolvins and protectins. J Immunol 2005; 174: 43454355.
  • 6
    Serhan CN,Gotlinger K,Hong S, et al. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: An overview of their protective roles in catabasis. Prostaglandins Other Lipid Mediat 2004; 73: 155172.
  • 7
    Weller CL,Collington SJ,Brown JK, et al. Leukotriene B-4, an activation product of mast cells, is a chemoattractant for their progenitors. J Exp Med 2005; 201: 19611971.
  • 8
    Chung JW,Kim GY,Mun YC, et al. Leukotriene B-4 pathway regulates the fate of the hematopoietic stem cells. Exp Mol Med 2005; 37: 4550.
  • 9
    Lacey DL,Erdmann JM,Teitelbaum SL, et al. Interleukin-4, interferon-γ, and prostaglandin-E impact the osteoclastic cell-forming potential of murine bone-marrow macrophages. Endocrinology 1995; 136: 23672376.
  • 10
    Collins DA,Chambers TJ. Effect of prostaglandins-E1, E2, and F2-α on osteoclast formation in mouse bone-marrow cultures. J Bone Miner Res 1991; 6: 157164.
  • 11
    Jagels MA,Hugli TE. Neutrophil chemotactic factors promote leukocytosis—A common mechanism for cellular recruitment from bone-marrow. J Immunol 1992; 148: 11191128.
  • 12
    Wada K,Arita M,Nakajima A, et al. Leukotriene B-4 and lipoxin A(4) are regulatory signals for neural stem cell proliferation and differentiation. FASEB J 2006; 20: 17851792.
  • 13
    Fischer CP,Berntsen A,Perstrup LB, et al. Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity. Scand J Med Sci Sports 2007; 17: 580587.
  • 14
    Nakamura Y,Ueno Y,Tamaki S, et al. Fish consumption and early atherosclerosis in middle-aged men. Metabolism 2007; 56: 10601064.
  • 15
    Cauley JA,Danielson ME,Boudreau RM, et al. Inflammatory markers and incident fracture risk in older men and women: The health aging and body composition study. J Bone Miner Res 2007; 22: 10881095.
  • 16
    Chung HY,Sung B,Jung KJ, et al. The molecular inflammatory process in aging. Antioxidants Redox Signaling 2006; 8: 572581.
  • 17
    De Souza CT,Araujo EP,Bordin S, et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005; 146: 41924199.
  • 18
    Schulze MB,Hoffmann K,Manson JE, et al. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr 2005; 82: 675684.
  • 19
    Blasko I,Stampfer-Kountchev M,Robatscher P, et al. How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: The role of microglia and astrocytes. Aging Cell 2004; 3: 169176.
  • 20
    Esposito K,Pontillo A,Di Palo C, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women—A randomized trial. JAMA 2003; 289: 17991804.
  • 21
    Bruunsgaard H,Pedersen M,Pedersen BK. Aging and proinflammatory cytokines. Curr Opin Hematol 2001; 8: 131136.
  • 22
    Dasilva J,Peers S,Perretti M, et al. Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1. J Endocrinol 1993; 136: 389397.
  • 23
    Seale JV,Wood SA,Atkinson HC, et al. Gonadal steroid replacement reverses gonadectomy-induced changes in the corticosterone pulse profile and stress-induced hypothalamic-pituitary-adrenal axis activity of male and female rats. J Neuroendocrinol 2004; 16: 989998.
  • 24
    Björntorp P. Alterations in the Ageing Corticotropic Stress-Response Axis. Novartis Foundation Symposium 242, Endocrine Facets of Ageing. West Sussex: Wiley; 2002.
  • 25
    Blackwell GJ,Carnuccio R,Dirosa M, et al. Macrocortin—A polypeptide causing the anti-phospholipase effect of glucocorticoids. Nature 1980; 287: 147149.
  • 26
    Masferrer J,Seibert K,Zweifel B, et al. Endogenous glucocorticoids regulate an inducible cyclooxgenase. Proc Natl Acad Sci USA 1992; 89: 39173921.
  • 27
    Goppelt-Struebe M,Wolter D,Resch K. Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclooxygenase/PGE isomerase. Br J Pharmacol 1989; 98: 12871295.
  • 28
    Fisch B,Rose MP,Elder MG, et al. Effects of estrogen on progesterone synthesis and arachidonic acid metabolism in human luteal cells. Clin Endocrinol 1994; 40: 2132.
  • 29
    Ham E,Cirillo V,Zanetti M, et al. Estrogen-directed synthesis of specific prostaglandins in uterus. Proc Natl Acad Sci USA 1975; 72: 14201424.
  • 30
    Blackwell GJ,Carnuccio R,Dirosa M, et al. Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal-cavity of the rat. Br J Pharmacol 1982; 76: 185194.
  • 31
    Masuzawa T,Miyaura C,Onoe Y, et al. Estrogen deficiency stimulates B-lymphopoiesis in mouse bone marrow. J Clin Invest 1994; 94: 10901097.
  • 32
    Erben RG,Raith S,Eberle J, et al. Ovariectomy augments B lymphopoiesis and generation of monocyte-macrophage precursors in rat bone marrow. Am J Physiol 1998; 37: E476E483.
  • 33
    Shevde NK,Pike JW. Estrogen modulates the recruitment of myelopoietic cell progenitors in rat through a stromal cell-independent mechanism involving apoptosis. Blood 1996; 87: 26832692.
  • 34
    Feyen JHM,Raisz LG. Prostaglandin production by calvariae from sham operated and oophorectomized rats—Effect of 17-β-estradiol in vivo. Endocrinology 1987; 121: 819821.
  • 35
    Maccarrone M,Bari M,Battista N, et al. Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. Blood 2002; 100: 40404048.
  • 36
    Kawaguchi H,Pilbeam CC,Vargas SJ, et al. Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae. J Clin Invest 1995; 96: 539548.
  • 37
    Carlsten H. Immune responses and bone loss: The estrogen connection. Immunol Rev 2005; 208: 194206.
  • 38
    Sites CK,Toth MJ,Cushman M, et al. Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal. Fertil Steril 2002; 77: 128135.
  • 39
    Bismar H,Diel I,Ziegler R, et al. Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement. J Clin Endocrinol Metab 1995; 80: 33513355.
  • 40
    Watkins BA,Shen CL,Allen KGD, et al. Dietary (n-3) and (n-6) polyunsaturates and acetylsalicylic acid alter ex vivo PGE(2) biosynthesis, tissue IGF-I levels, and bone morphometry in chicks. J Bone Miner Res 1996; 11: 13211332.
  • 41
    Profita M,Vignola AM,Sala A, et al. Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15(S)-HETE into cellular phospholipids in cultured pulmonary epithelial cells. Am J Respir Cell Mol Biol 1999; 20: 6168.
  • 42
    Gross E,Ruzicka T,Vonrestorff B, et al. High-affinity binding and lack of growth-promoting activity of 12(S)-hydroxyeicosatetraenoic acid (12(S)-Hete) in a human epidermal-cell line. J Invest Dermatol 1990; 94: 446451.
  • 43
    Traianedes K,Dallas MR,Garrett IR, et al. 5-Lipoxygenase metabolites inhibit bone formation in vitro. Endocrinology 1998; 139: 31783184.
  • 44
    Mayser P,Mrowietz U,Arenberger P, et al. Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: Results of a double-blind, randomized, placebo-controlled, multicenter trial. J Am Acad Dermatol 1998; 38: 539547.
  • 45
    Yokoyama A,Hamazaki T,Ohshita A, et al. Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma. Int Arch Allergy Immunol 2000; 123: 327332.
  • 46
    Nagakura T,Matsuda S,Shichijyo K, et al. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. Eur Respir J 2000; 16: 861865.
  • 47
    Kruger M,Coetzer H,de Winter R, et al. Calcium, γ-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. Aging Clin Exp Res 1998; 10: 385394.
  • 48
    Kruger M,Claassen N,Schlemmer C, et al. Essential fatty acid supplementation: Effect on oestrogen deficiency induced bone loss in the female rat. Calcif Tissue Int 1999; 64: 63.
  • 49
    Watkins BA,Li Y,Seifert MF. Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: Actions on bone mineral and serum biomarkers in ovariectomised rats. J Nutr Biochem 2006; 17: 282289.
  • 50
    Ashton I,Clements K,Barrow SE, et al. Effects of dietary fatty-acids on eicosanoid-generating capacity, fatty-acid composition and chemotactic activity of rainbow-trout (Oncorhynchus-mykiss) leukocytes. Biochim Biophys Acta 1994; 1214: 253262.
  • 51
    Gonzalez-Periz A,Palanaguma A,Gronert K, et al. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: Protectin D1 and 17S-hydroxy-DHA. FASEB J 2006; 20: 25372539.
  • 52
    Gerster H. Can adults adequately convert α-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? Int J Vitam Nutr Res 1998; 68: 159173.
  • 53
    Poulsen RC,Kruger MC. Detrimental effect of eicosapentaenoic acid supplementation on bone following ovariectomy in rats. Prostaglandins Leukot Essent Fatty Acids 2006; 75: 419427.
  • 54
    Kruger MC,Schollum LM. Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? Prostaglandins Leukot Essent Fatty Acids 2005; 73: 327334.
  • 55
    Bathija A,Davis S,Trubowitz S. Bone marrow adipose tissue: Response to acute starvation. Am J Hematol 1979; 6: 191198.
  • 56
    Ariel A,Li P-L,Wang W, et al. The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. J Biol Chem 2005; 280: 4307943086.
  • 57
    Mukherjee PK,Marcheselli VL,Serhan CN, et al. Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci USA 2004; 101: 84918496.
  • 58
    Hasturk H,Kantarci A,Ohira T, et al. RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis. FASEB J 2005; 19: 401403.
  • 59
    Duffield J,Hong S,Vaidya V, et al. Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol 2006; 177: 59025911.
  • 60
    Arita M,Yoshida M,Hong S, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci USA 2005; 102: 76717676.
  • 61
    Marcheselli VL,Hong S,Lukiw WJ, et al. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 2003; 278: 4380743817.
  • 62
    Teggatz EG,Hong S,Siebenaler JF, et al. Mechanism mediating the action of omega-3 PUFA: Potent coronary vasodilation of resolvins, novel docosanoids. FASEB J 2004; 18: A981A981.
  • 63
    Lukiw WJ,Cui JG,Marcheselli VL, et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 2005; 115: 27742783.
  • 64
    National Research Council. Nutrient Requirements of Laboratory Animals Fourth Revised Edition. Washington DC: National Academy Press; 1995.
  • 65
    James K,Butts C,Hardacre A, et al. The effect of drying room temperature on the nutritional quality of New Zealand-grown maize for growing rats. J Sci Food Agric 2004; 84: 147157.
  • 66
    Scutt A,Reading L,Scutt N, et al. Mineralizing fibroblast-colony-forming assays. In: HelfrichM,RalstonS, editors. Methods in Molecular Medicine,Bone Research Protocols, Vol. 80. Totowa, NJ: Humana Press; 2003. pp 2939.
  • 67
    Lu Y,Hong S,Gotlinger K, et al. Lipid mediator informatics and proteomics in inflammation-resolution. Sci World J 2006; 6: 589614.
  • 68
    Hong S,Lu Y,Yang R, et al. Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. J Am Soc Mass Spectrom 2007; 18: 128144.