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Laboratory testing for fibrinogen abnormalities†

  1. Madeleine Verhovsek1,2,
  2. Karen A. Moffat2,3,
  3. Catherine P.M. Hayward1,2,3,*

Article first published online: 23 SEP 2008

DOI: 10.1002/ajh.21293

Issue

American Journal of Hematology

American Journal of Hematology

Volume 83, Issue 12, pages 928–931, December 2008

Additional Information

How to Cite

Verhovsek, M., Moffat, K. A. and Hayward, C. P.M. (2008), Laboratory testing for fibrinogen abnormalities. Am. J. Hematol., 83: 928–931. doi: 10.1002/ajh.21293

Author Information

  1. 1

    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

  2. 2

    Department of Medicine, McMaster University, Hamilton, Ontario, Canada

  3. 3

    Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada

*Room 2N30, McMaster University Medical Center, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5

  1. †

    Conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 20 NOV 2008
  2. Article first published online: 23 SEP 2008
  3. Accepted manuscript online: 23 SEP 2008 12:00AM EST
  4. Manuscript Accepted: 13 SEP 2008
  5. Manuscript Revised: 11 SEP 2008
  6. Manuscript Received: 9 JUL 2008

Funded by

  • Career Investigator Award from the Heart and Stroke Foundation of Ontario
  • Canada Research Chair in Molecular Hemostasis

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Abstract

Fibrinogen is essential for the formation of a fibrin clot. Acquired and congenital disorders of fibrinogen may result in decreased concentration or altered function of fibrinogen, often leading to an increased risk of bleeding. Routine coagulation testing and specialized laboratory investigations can guide diagnosis in patients suspected of having a fibrinogen abnormality. This article summarizes the types of laboratory assays that are used to assess fibrinogen disorders, and key abnormalities found in different types of fibrinogen disorders.disorders. Am. J. Hematol., 2008. © 2008 Wiley-Liss, Inc.

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