Research Article

You have full text access to this OnlineOpen article

Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant†

  1. Paul M. Barr1,*,
  2. Hillard M. Lazarus1,
  3. Brenda W. Cooper1,
  4. Mark D. Schluchter2,
  5. Ashok Panneerselvam2,
  6. James W. Jacobberger3,
  7. Jack W. Hsu4,
  8. Nalini Janakiraman5,
  9. Aleksandra Simic6,
  10. Afshin Dowlati1,
  11. Scot C. Remick7

Article first published online: 11 MAY 2009

DOI: 10.1002/ajh.21449

Issue

American Journal of Hematology

American Journal of Hematology

Volume 84, Issue 8, pages 484–487, August 2009

Additional Information

How to Cite

Barr, P. M., Lazarus, H. M., Cooper, B. W., Schluchter, M. D., Panneerselvam, A., Jacobberger, J. W., Hsu, J. W., Janakiraman, N., Simic, A., Dowlati, A. and Remick, S. C. (2009), Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant. Am. J. Hematol., 84: 484–487. doi: 10.1002/ajh.21449

Author Information

  1. 1

    Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio

  2. 2

    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio

  3. 3

    Department of Genetics, Case Western Reserve University, Cleveland, Ohio

  4. 4

    Department of Medicine, University of Florida Shands Cancer Center, Gainesville, Florida

  5. 5

    Department of Medicine, Henry Ford Medical Center, Detroit, Michigan

  6. 6

    Department of Medicine, Oregon Health Sciences University, Portland, Oregon

  7. 7

    Department of Medicine, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia

*University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Ave, WRN 5065, Cleveland, OH 44106

  1. †

    Conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 24 JUL 2009
  2. Article first published online: 11 MAY 2009
  3. Accepted manuscript online: 11 MAY 2009 12:00AM EST
  4. Manuscript Accepted: 4 MAY 2009
  5. Manuscript Revised: 1 MAY 2009
  6. Manuscript Received: 10 MAR 2009

Funded by

  • National Institutes of Health. Grant Numbers: CA62502, M01-RR-00080

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (115K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Emma Dean, Alastair Greystoke, Malcolm Ranson, Caroline Dive, Biomarkers of cell death applicable to early clinical trials, Experimental Cell Research, 2012, 318, 11, 1252

    CrossRef

  2. 2
    Kazuhiro Irie, Ryo C. Yanagita, Yu Nakagawa, Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ, Medicinal Research Reviews, 2012, 32, 3
    Direct Link:
  3. 3
    Ji Lu, Zhenlei Song, Yuebao Zhang, Zubao Gan, Hongze Li, Prins Cyclization of Bis(silyl) Homoallylic Alcohols to Form 2,6-cis-Tetrahydropyrans Containing a Geometrically Defined Exocyclic Vinylsilane: Efficient Synthesis of Ring B of the Bryostatins, Angewandte Chemie International Edition, 2012, 51, 22
    Direct Link:
  4. 4
    Ji Lu, Zhenlei Song, Yuebao Zhang, Zubao Gan, Hongze Li, Prins Cyclization of Bis(silyl) Homoallylic Alcohols to Form 2,6-cis-Tetrahydropyrans Containing a Geometrically Defined Exocyclic Vinylsilane: Efficient Synthesis of Ring B of the Bryostatins, Angewandte Chemie, 2012, 124, 22
    Direct Link:
  5. 5
    Masayuki Kikumori, Ryo C Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Kazuhiro Irie, Structure–Activity Studies on the Spiroketal Moiety of a Simplified Analog of Debromoaplysiatoxin with Antiproliferative Activity, Journal of Medicinal Chemistry, 2012, 120524114955003

    CrossRef

  6. 6
    Kazuhiro Irie, Masayuki Kikumori, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Ryo C. Yanagita, Harukuni Tokuda, Nobutaka Suzuki, Hiroshi Nagai, Kiyotake Suenaga, Yu Nakagawa, Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1, Pure and Applied Chemistry, 2012, 84, 6, 1341

    CrossRef

  7. 7
    Paul A. Wender, Jenny Reuber, Function oriented synthesis: preparation and initial biological evaluation of new A-ring-modified bryologs, Tetrahedron, 2011, 67, 51, 9998

    CrossRef

  8. 8
    Richard V. Davis, Lisa N. McKernan, Jennifer Rhodes, Joseph Kulkosky, In Vivo Effects of Antiviral Protein Kinase C Modulators on Zebrafish Development and Survival, ISRN Toxicology, 2011, 2011, 1

    CrossRef

  9. 9
    John W. Blunt, Brent R. Copp, Murray H. G. Munro, Peter T. Northcote, Michèle R. Prinsep, Marine natural products, Natural Product Reports, 2011, 28, 2, 196

    CrossRef

  10. 10
    P. A. Wender, J. L. Baryza, S. E. Brenner, B. A. DeChristopher, B. A. Loy, A. J. Schrier, V. A. Verma, Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity, Proceedings of the National Academy of Sciences, 2011, 108, 17, 6721

    CrossRef

  11. 11
    Yunkun Qi, Shutao Ma, The Medicinal Potential of Promising Marine Macrolides with Anticancer Activity, ChemMedChem, 2011, 6, 3
    Direct Link:
  12. 12
    Paul A. Wender, Adam J. Schrier, Total Synthesis of Bryostatin 9, Journal of the American Chemical Society, 2011, 133, 24, 9228

    CrossRef

  13. 13
    Paul A. Wender, Brian A. Loy, Adam J. Schrier, Translating Nature’s Library: The Bryostatins and Function-Oriented Synthesis, Israel Journal of Chemistry, 2011, 51, 3-4
    Direct Link:
  14. 14
    David Newman, Anticancer Agents from Natural Products, Second Edition, 2011,

    CrossRef

  15. 15
    Jörn Piel, Biosynthesis of polyketides by trans-AT polyketide synthases, Natural Product Reports, 2010, 27, 7, 996

    CrossRef

  16. 16
    Ioana Abraham, Sandeep Jain, Chung-Pu Wu, Mohammad A. Khanfar, Yehong Kuang, Chun-Ling Dai, Zhi Shi, Xiang Chen, Liwu Fu, Suresh V. Ambudkar, Khalid El Sayed, Zhe-Sheng Chen, Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells, Biochemical Pharmacology, 2010, 80, 10, 1497

    CrossRef

  17. 17
    Sophie Dupire, Bertrand Coiffier, Targeted treatment and new agents in diffuse large B cell lymphoma, International Journal of Hematology, 2010, 92, 1, 12

    CrossRef

Get PDF (115K)