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Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease†

  1. Nilesh R. Ghugre1,2,
  2. Ignacio Gonzalez-Gomez3,
  3. Ellen Butensky4,
  4. Leila Noetzli1,
  5. Roland Fischer5,6,
  6. Roger Williams7,
  7. Paul Harmatz4,
  8. Thomas D. Coates3,8,
  9. John C. Wood1,2,*

Article first published online: 18 MAY 2009

DOI: 10.1002/ajh.21456

Issue

American Journal of Hematology

American Journal of Hematology

Volume 84, Issue 8, pages 480–483, August 2009

Additional Information

How to Cite

Ghugre, N. R., Gonzalez-Gomez, I., Butensky, E., Noetzli, L., Fischer, R., Williams, R., Harmatz, P., Coates, T. D. and Wood, J. C. (2009), Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease. Am. J. Hematol., 84: 480–483. doi: 10.1002/ajh.21456

Author Information

  1. 1

    Division of Cardiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California

  2. 2

    Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California

  3. 3

    Department of Pathology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California

  4. 4

    Department of Gastroenterology and Nutrition, Children's Hospital and Research Center at Oakland, Oakland, California

  5. 5

    Pediatric Clinical Research Center, Children's Hospital and Research Center at Oakland, Oakland, California

  6. 6

    Department of Pediatric Hematology-Oncology, University Clinic Hamburg-Eppendorf, Hamburg, Germany

  7. 7

    Department of Pathology, Children's Hospital and Research Center at Oakland, Oakland, California

  8. 8

    Division of Hematology-Oncology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California

*Division of Cardiology, Mailstop #34, Children's Hospital Los Angeles, 4650 Sunset Blvd., Los Angeles, CA 90027-0034

  1. †

    Conflict of Interest: Dr. Wood, Dr. Coates, and Dr. Harmatz have research funding from Novartis and had received speakers honoraria from Novartis and Apotex.

Publication History

  1. Issue published online: 24 JUL 2009
  2. Article first published online: 18 MAY 2009
  3. Accepted manuscript online: 18 MAY 2009 12:00AM EST
  4. Manuscript Accepted: 13 MAY 2009
  5. Manuscript Revised: 12 MAY 2009
  6. Manuscript Received: 20 OCT 2008

Funded by

  • National Institutes of Health (General Clinical Research Center). Grant Number: RR00043-43
  • Pediatric Clinical Research Center at the Children's Hospital & Research Center, Oakland. Grant Number: M01 RR01271
  • Center for Disease Control (Thalassemia Center). Grant Number: U27/CCU922106
  • Department of Pediatrics at Children's Hospital Los Angeles (CHLA)
  • National Heart Lung and Blood Institute of the National Institutes of Health. Grant Number: 1 R01 HL75592-01A1
  • National Institute for Diabetes, Digestion, and Kidney Disease. Grant Number: R01 DK057778
  • Saban Research Institute at CHLA

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This article has been cited by:

  1. 1
    Adlette Inati, Evelyne Khoriaty, Khaled M. Musallam, Iron in sickle-cell disease: What have we learned over the years?, Pediatric Blood & Cancer, 2011, 56, 2
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  2. 2
    Iron-Chelating Therapy for Transfusional Iron Overload, New England Journal of Medicine, 2011, 364, 15, 1475

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  3. 3
    Nilesh R. Ghugre, John C. Wood, Relaxivity-iron calibration in hepatic iron overload: Probing underlying biophysical mechanisms using a Monte Carlo model, Magnetic Resonance in Medicine, 2011, 65, 3
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