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Research Article
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Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomib†
Article first published online: 30 JUL 2009
DOI: 10.1002/ajh.21517
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Sood, R., Carloss, H., Kerr, R., Lopez, J., Lee, M., Druck, M., Walters, I. B. and Noga, S. J. (2009), Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomib. Am. J. Hematol., 84: 657–660. doi: 10.1002/ajh.21517
- †
Publication History
- Issue published online: 25 SEP 2009
- Article first published online: 30 JUL 2009
- Accepted manuscript online: 30 JUL 2009 12:00AM EST
- Manuscript Accepted: 28 JUL 2009
- Manuscript Revised: 27 JUL 2009
- Manuscript Received: 3 APR 2009
Funded by
- Millennium Pharmaceuticals, Inc.
- Johnson & Johnson Pharmaceuticals Research & Development, LLC
References
- 1VELCADE® (Bortezomib) for Injection. Prescribing Information. Cambridge, MA: Millennium Pharmaceuticals, Inc., 2008.
- 2,,, et al. United States Food and Drug Administration approval summary: Bortezomib for the treatment of progressive multiple myeloma after one prior therapy. Clin Cancer Res 2006; 12: 2955–2960.
- 3,,, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 2008; 359: 906–917.
- 4,,, et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 2004; 127: 165–172.
- 5,,, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003; 348: 2609–2617.
- 6,,, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005; 352: 2487–2498.
- 7,,, et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: Final time-to-event results of the APEX trial. Blood 2007; 110: 3557–3560.
- 8National Comprehensive Cancer Network. Guidelines accessed from NCCN website March 2009. Available at: http://www.nccn.org/professionals/ physician_gls/PDF/myeloma.pdf.
- 9,,, et al. Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression. J Clin Oncol 2007; 25: 3892–3901.
- 10,,, et al. Beyond single-agent bortezomib: Combination regimens in relapsed multiple myeloma. Curr Opin Oncol 2006; 18: 598–608.
- 11,,, et al. Feasibility and efficacy of bortezomib re-treatment in multiple myeloma. Haematologica 2007; 92: 95; Abstract 260.
- 12,,, et al. An observational, retrospective analysis of retreatment with bortezomib for multiple myeloma. Clin Lymphoma Myeloma 2008; 8: 140–145.
- 13,,, et al. Bortezomib retreatment in relapsed multiple myeloma (MM): Results from a binational, multicenter retrospective study. Blood 2008: 112; Abstract 2775.
- 14,,, et al. Response to bortezomib in relapsed/refractory multiple myeloma cohort. Haematologica 2007; 92: 472; Abstract 1305.
- 15,,, et al. Response to re-treatment on relapse multiple myeloma patients previously treated with bortezomib. Haematologica 2008; 93: 261 (Abstract 649).
- 16,,, et al. Utility of bortezomib retreatment in relapsed or refractory multiple myeloma patients: A multicenter case series. Clin Adv Hematol Oncol 2008; 6: 755–760.
- 17,,, et al. Efficacy and safety of re-treatment with bortezomib (Velcade®) in patients with multiple myeloma: Results from a prospective international Phase II trial. Blood 2008: 112; Abstract 3690.
- 18,,, et al. Safety and efficacy of bortezomib and melphalan combination in patients with relapsed or refractory multiple myeloma: Updated results of a phase 1/2 study after longer follow-up. Ann Hematol 2008; 87: 623–631.
- 19,,, et al. Final results of a phase II study of bortezomib (Velcade) in combination with liposomal doxorubicin (Doxil) and thalidomide (VDT) demonstrate a sustained high response rates in patients (pts) with relapsed (rel) or refractory (ref) multiple myeloma. Blood 2006; 108: 1010a; Abstract 3539.
- 20,,, et al. The addition of liposomal doxorubicin to bortezomib, thalidomide and dexamethasone significantly improves clinical outcome of advanced multiple myeloma. Br J Haematol 2008; 141: 814–819.
- 21,,, et al. A new model predicting at least a very good partial response in patients with multiple myeloma (MM) after 2 cycles of bortezomib-based therapy. Haematologica 2006; 91: 273; Abstract 741.
- 22,,, et al. Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma. Ann Oncol 2008; 19: 1160–1165.
- 23,,, et al. Phase I/II results of a multicenter trial of perifosine (KRX-0401) + bortezomib in patients with relapsed or relapsed/refractory multiple myeloma who were previously relapsed from or refractory to bortezomib. Blood 2008: 112; Abstract 870.
- 24,,, et al. Lenalidomide plus bortezomib (Rev-Vel) in relapsed and/or refractory multiple myeloma (MM): Final results of a multicenter phase 1 trial. Blood 2006; 108: 124a; Abstract 405.
- 25,,, et al. Lenalidomide, bortezomib, and dexamethasone (Len/Bz/Dex) in patients with relapsed or relapsed/refractory multiple myeloma (MM): Encouraging response rates and tolerability with correlation of outcome and adverse cytogenetics in a phase II study. Blood 2008: 112; Abstract 1742.
- 26,,, et al. Combination of vorinostat plus bortezomib for the treatment of patients with multiple myeloma who have previously received bortezomib. Blood 2008: 112; Abstract 3711.

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