Conflict of interest: Nothing to report.
Sickle cell disease in the United States: Looking back and forward at 100 years of progress in management and survival†
Article first published online: 8 FEB 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Hematology
Volume 85, Issue 5, pages 346–353, May 2010
How to Cite
Prabhakar, H., Haywood, C. and Molokie, R. (2010), Sickle cell disease in the United States: Looking back and forward at 100 years of progress in management and survival. Am. J. Hematol., 85: 346–353. doi: 10.1002/ajh.21676
- Issue published online: 21 APR 2010
- Article first published online: 8 FEB 2010
- Accepted manuscript online: 8 FEB 2010 12:00AM EST
- Manuscript Accepted: 1 FEB 2010
- Manuscript Revised: 31 JAN 2010
- Manuscript Received: 3 OCT 2009
The past 100 years since James Herrick's first description of sickle cell disease in the United States have been characterized by the gradual development of management strategies. We review the progress in sickle cell disease management in the United States over the past 100 years, with emphasis on the diverse forces surrounding advances in disease management. Mortality and survival data are presented chronologically, with an attempt to highlight improvements in survival associated with specific advancements for pediatric and adult care. Finally, the future course for sickle cell disease management is explored, given the continued work in advancing the field. Am. J. Hematol. 2010. © 2010 Wiley-Liss, Inc.