Conflict of interest: Nothing to report.
Test of the Month
Laboratory tests for antithrombin deficiency †
Article first published online: 23 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
American Journal of Hematology
Volume 85, Issue 12, pages 947–950, December 2010
How to Cite
Khor, B. and Van Cott, E. M. (2010), Laboratory tests for antithrombin deficiency . Am. J. Hematol., 85: 947–950. doi: 10.1002/ajh.21893
- Issue published online: 23 NOV 2010
- Article first published online: 23 NOV 2010
- Accepted manuscript online: 30 SEP 2010 12:00AM EST
- Manuscript Accepted: 23 SEP 2010
- Manuscript Received: 17 SEP 2010
Hereditary antithrombin deficiency is a hypercoagulable state associated with an increased risk for venous thrombosis. The recommended initial test for antithrombin is an activity (functional) assay. The advantages and disadvantages of the various testing options are presented. The causes of acquired antithrombin deficiency are much more common than hereditary deficiency. Therefore, this article describes the appropriate steps to take when antithrombin activity is low, in order to confirm or exclude a hereditary deficiency. The causes of falsely normal results are also described, including direct thrombin inhibitors. Am. J. Hematol. 85:947–950, 2010. © 2010 Wiley-Liss, Inc.