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1 Subtype of circulating dendritic cells that express surface markers CD123, CD303, and CD304, but do not express CD11c or CD14 – the putative cell of origin of a very rare form of leukemia that often first manifests in the skin

9 An easily digestible starch made from cassava roots, frequently formed into “pearls” and traditionally fed to children and invalids, including the first reported patient with multiple myeloma in the 1840s

10 The world's most popular recreational drug… and the one that kills the most people

11 Eponym for the muscular sphincter that controls the flow of digestive juices through the ampulla of Vater; named after an Italian medical student who re-described the structure in the 1887, more than 230 years after its description by British anatomist Francis Glisson

12 A form of aneuploidy in which one chromosome of a pair is missing; in myelodysplasia, this class of karyotype confers a dismal prognosis, even after allogeneic stem cell transplantation

15 General term for a fatty acid with a carbohydrate attached; one type accumulates in Gaucher disease, another in the disease described in 25 Down

16 Acronym for a large cancer-focused medical society with a long-term contract to (tediously but economically) hold all of its annual meetings at Chicago's McCormick Place

17 Pig fat once used commonly as a shortening or a butter-like spread; also an unkind nickname that could be applied to participants on NBC television's program, “The Biggest Loser”

19 A toxic antibiotic once prescribed to treat staphylococcal infections, but now used in the laboratory diagnosis of Bernard-Soulier syndrome and von Willebrand disease

21 The part of a country distant from a coastline

22 In 1906, this young house officer described intracellular inclusions in white cells he called “large lymphocytes”, found on a blood smear from a 21-year-old man with epistaxis and pharyngitis who had been admitted to William Osler's service at Johns Hopkins Hospital; a century later, these eponymous structures remain a morphologic hallmark of myeloid leukemia

24 Connective tissue protein that is defective in Williams-Beuren and Marfan syndromes

27 Binge-and-purge eating disorder named after oxen; associated micronutrient deficiencies can cause various erythrocyte abnormalities

28 Anterior pituitary-derived peptide hormone that regulates a shield-shaped gland in the neck; severe deficiency can cause macrocytic anemia (British spelling)

Down

2 Mycobacterial infection rarely associated with antiphospholipid antibodies, anemia, or leukopenia; contrary to folklore, it does not cause body parts to spontaneously detach

3 Gelatinous substance derived from red algae, useful both for making desserts and for growing hematopoietic progenitor colonies

4 Both bored children on long car trips and patients undergoing prolonged treatments may ask: “Are we there ___?”

5 Acronym that means the patient can get up and ambulate

6 Médecins; artsen; medici; doutores; γιατρOι; equation imageOKTOpa; Ärzte; equation image

7 Genus of worm commonly considered in the evaluation of eosinophilia

8 Patients with erythrocytosis and a high serum erythropoietin level may need one of these overnight studies to search for a cause

13 An alkaloid of the Papaver somniferum poppy plant

14 Experiments conducted in test tubes or Petri dishes are done in vitro; in live animals or humans, in vivo; in computers, in _______

18 An author who falsifies data or “fudges” experiments may one day be forced to do this to a published paper, causing grave embarassment and perhaps severe institutional sanctions

20 Medical argot for blood clots

23 Small nuclear RNAs transcribed by host RNA polymerase III during latent infection with Epstein-Barr virus; a useful marker in the diagnosis of post-transplant lymphoproliferative disorders

25 British ophthalmologist who in 1881 described retinal red spots in a tragic, incurable syndrome due to Hexosaminidase A deficiency—a syndrome that would later take his name

26 Collective acronym for groups such as Médecins Sans Frontières, Partners in Health/Zanmi Lasante, or Rotary International that operate independent of national ruling political bodies; more than 40,000 exist internationally, while India alone has more than 1 million