Conflict of interest: Nothing to report.
Bone Marrow Update
Bone marrow aspirate and trephine biopsy findings in lymphoplasmacytic lymphoma†
Article first published online: 15 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Hematology
Volume 86, Issue 3, pages 311–312, March 2011
How to Cite
Naresh, K. N., Trivedi, P., Luqmani, A. and Rahemtulla, A. (2011), Bone marrow aspirate and trephine biopsy findings in lymphoplasmacytic lymphoma. Am. J. Hematol., 86: 311–312. doi: 10.1002/ajh.21925
- Issue published online: 23 FEB 2011
- Article first published online: 15 FEB 2011
- Accepted manuscript online: 15 NOV 2010 10:56AM EST
- Manuscript Accepted: 29 OCT 2010
- Manuscript Received: 25 OCT 2010
The majority of patients with LPL present with anemia. Most have an IgM paraprotein. Rarely both IgM and IgG or other paraproteins may be present. About 30% of patients present with hyperviscosity and features of WM. In a proportion of cases, some cells within the infiltrate have intranuclear cytoplasmic pseudo-inclusions (Dutcher bodies). Differentiation of LPL from bone marrow involvement by marginal zone lymphoma (MZL) with plasmacytic differentiation is particularly challenging, and a diagnosis of MZL at another site should be excluded before arriving at a diagnosis of LPL. There are no characteristic/consistent cytogenetic abnormalities among LPL [1, 2].1
- 2Lymphoplasmacytic lymphoma. In: SwerdlowSH, CampoE, HarrisNL, , , , , (ed): WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC; 2008. pp 194–195., , , , , .