Conflict of interest: Nothing to report.
Hemosiderin-containing plasma cells†
Version of Record online: 12 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Hematology
Volume 87, Issue 8, page 815, August 2012
How to Cite
Bain, B. J. (2012), Hemosiderin-containing plasma cells. Am. J. Hematol., 87: 815. doi: 10.1002/ajh.22234
- Issue online: 17 JUL 2012
- Version of Record online: 12 NOV 2011
- Accepted manuscript online: 22 OCT 2011 11:55PM EST
- Manuscript Accepted: 19 OCT 2011
- Manuscript Received: 18 OCT 2011
The illustrated bone marrow plasma cells (left and right) are from a 49-year-old woman with refractory anemia with multilineage dysplasia. They contain hemosiderin deposits. Since such deposits were first described in 1978 , there have been more than a dozen reports of such inclusions. They have been linked to iron overload (transfusional hemosiderosis, genetic hemochromatosis, myelodysplastic syndromes, congenital sideroblastic anemia) , copper deficiency , and bone marrow impairment caused by heavy alcohol intake [2, 4, 5]. Hemosiderin deposits in plasma cells have a deep-blue to greenish black color on a Romanowsky-type stain. Their nature can be confirmed by a Perls' Prussian blue stain. In the present patient, there was also increased macrophage iron but iron-laden plasma cells can occur in alcoholism without any necessity for there to be iron overload . The detection of hemosiderin in plasma cells in this patient was the first indication of a previously unadmitted heavy alcohol intake.