Conflict of interest: Consultant for Ziopharm, Seattle Genetics, Genentech, Allos, Roche.
A Continuing Medical Education Series
The aggressive peripheral T-cell lymphomas: 2012 update on diagnosis, risk stratification, and management†
Article first published online: 17 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Hematology
Volume 87, Issue 5, pages 511–519, May 2012
How to Cite
Armitage, J. O. (2012), The aggressive peripheral T-cell lymphomas: 2012 update on diagnosis, risk stratification, and management. Am. J. Hematol., 87: 511–519. doi: 10.1002/ajh.23144
- Issue published online: 16 APR 2012
- Article first published online: 17 APR 2012
- Manuscript Accepted: 30 JAN 2012
- Manuscript Received: 27 JAN 2012
Background: T-cell lymphomas make up approximately 10–15% of lymphoid malignancies. The frequency of these lymphomas varies geographically, with the highest incidence in parts of Asia. Diagnosis: The diagnosis of aggressive peripheral T-cell lymphoma (PTCL) is usually made using the WHO classification. The ability of hematopathologists to reproducibly diagnose aggressive PTCL is lower than for aggressive B-cell lymphomas, with a range of 72–97% for the aggressive PTCLs. Risk Stratification: Patients with aggressive PTCL are staged using the Ann Arbor Classification. Although somewhat controversial, positron emission tomography (PET) scans appear to be useful as they are in aggressive B-cell lymphomas. The most commonly used prognostic index is the International Prognostic Index. The specific subtype of aggressive PTCL is an important risk factor, with the best survival seen in anaplastic large-cell lymphoma—particularly young patients with the anaplastic lymphoma kinase positive subtype. Risk Adapted Therapy: Anaplastic large-cell lymphoma is the only subgroup to have a good response to a cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)-like regimen. Angioimmunoblastic T-cell lymphoma has a prolonged disease-free survival in only ∼20% of patients, but younger patients who have an autotransplant in remission seem to do better. PTCL-not otherwise specified (NOS) is not one disease. Anthracycline containing regimens have disappointing results and a new approach is needed. NK/T-cell lymphoma localized to the nose and nasal sinuses seems to be best treated with radiotherapy containing regimens. Enteropathy associated PTCL and hepatosplenic PTCL are rare disorders with a generally poor response to therapy, although selected patients with enteropathy associated PTCL seem to benefit from intensive therapy. Am. J. Hematol. 87:511–519, 2012. © 2012 Wiley Periodicals, Inc.